STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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Atg5Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3- like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity). (269 aa)    
Predicted Functional Partners:
Atg3
Autophagy-related 3 (Atg3) encodes a protein involved in multiple autophagy processes such as autophagosome assembly, cellular response to starvation, and glycophagy.
   
 0.999
Atg12
Autophagy protein 12-like; Required for autophagy.
   
 0.999
Atg16
Autophagy-related 16 (Atg16) encodes a protein that forms an E3-like protein complex. This complex contributes to the the covalent binding of the lipid phosphatidylethanolamine to the product of Atg8a, a key autophagy protein involved in autophagosome biogenesis. The product of Atg16 is involved in autophagosome biogenesis, maintenance of proper neuromuscular function, lifespan, ethanol sedation, and enteroendocrine cell function in the intestine.
   
 0.999
Atg1
Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.
    
 
 0.998
Atg7
Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan.
   
 0.997
Atg8a
Autophagy-related 8a (Atg8a) encodes a ubiquitin-like protein that is conjugated to phosphatidylethanolamine, and this lipid modification anchors it into the membrane of forming and completed autophagosomes. Atg8a product has roles in autophagosome formation, maintaining neuromuscular function and normal lifespan.
   
 0.995
Atg8b
Autophagy-related 8b, isoform A; Microtubule binding; protein tag; ubiquitin protein ligase binding; GABA receptor binding. It is involved in the biological process described with: macroautophagy; autophagosome maturation; cellular response to nitrogen starvation; autophagy of mitochondrion; autophagosome assembly.
   
 0.994
Pi3K59F
Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis.
    
 0.989
Sirt1
NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span.
   
 
 0.986
Atg18a
Autophagy-related 18a (Atg18a) encodes a protein that regulates autophagy by participating in isolation membrane elongation around cytoplasmic cargoes.
    
 0.984
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.