STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MigaMitoguardin; Regulator of mitochondrial fusion required to maintain neuronal homeostasis. (525 aa)    
Predicted Functional Partners:
CG12123
GH02722p.
   
  
 0.918
CG32712
Uncharacterized protein.
 
    
 0.856
zuc
Mitochondrial cardiolipin hydrolase; Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes compose [...]
   
 
 0.744
CG1440
Uncharacterized protein, isoform D; Cysteine-type peptidase activity; cysteine-type endopeptidase activity. It is involved in the biological process described with: homocysteine catabolic process; response to toxic substance; proteolysis.
      
 0.669
Marf
Transmembrane GTPase Marf; Mitochondrial assembly regulatory factor (Marf) encodes a dynamin-family GTPase that mediates outer mitochondrial membrane tethering and fusion. Marf loss causes mitochondrial fragmentation and endoplasmic reticular stress that evoke skeletal muscle, retinal and heart tube dysfunction; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.
   
 
 0.597
org-1
Optomotor-blind-related-gene-1, isoform A; Optomotor-blind-related-gene-1 (org-1) encodes a T-box transcription factor involved in the combinatorial activation of somatic muscle lineage-specific targets.
      
 0.533
Vap33
VAMP-associated protein 33kDa, isoform B; VAMP-associated protein 33kDa (Vap33) encodes a protein that plays a conserved role in synaptic homeostasis. It controls a number of processes which depend on phosphoinositide levels, such as synaptic growth and axonal transport. It binds to the product of Sac1 to maintain normal levels of phosphoinositides and to the product of Dscam1 to affect its localization within axonal projections.
   
 
 0.520
CG13887
LP10861p; It is involved in the biological process described with: endoplasmic reticulum to Golgi vesicle-mediated transport; protein localization to endoplasmic reticulum exit site; intracellular protein transport.
      
 0.461
KrT95D
Krueppel target at 95D, isoform A; It is involved in the biological process described with: protein localization to plasma membrane.
      
 0.435
PAPLA1
Phosphatidic Acid Phospholipase A1 (PAPLA1) encodes a protein required for the endoplasmic reticulum to Golgi trafficking of a family of G-protein coupled receptors.
      
 0.426
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.