Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Blm | CG2990 | FBpp0081910 | FBpp0071350 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | FI06813p; 5'-flap endonuclease activity; RNA binding. It is involved in the biological process described with: DNA replication, Okazaki fragment processing; replication fork reversal. | 0.928 |
| Blm | Cdc45 | FBpp0081910 | FBpp0070175 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | CDC45L (CDC45L) encodes a protein that contributes to 3'-5' DNA helicase activity of the Cdc45/Mcm2-7/GINS complex. It is involved in chromosome condensation and the regulation of the mitotic G1/S transition. | 0.583 |
| Blm | Ctf4 | FBpp0081910 | FBpp0086732 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | Chromosome transmission fidelity 4; Chromatin binding. | 0.549 |
| Blm | DNApol-delta | FBpp0081910 | FBpp0075277 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | DNA polymerase delta catalytic subunit; As the catalytic component of the DNA polymerase delta complex, plays a crucial role in high fidelity genome replication, including lagging strand synthesis, DNA recombination and repair (By similarity). Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Required at the nucleus of rapidly dividing embryonic cells to activate genome replication during the earliest cell cycles. Likely to require the presence of accessory proteins Pol31 and Pol32 for full activity. | 0.583 |
| Blm | Fen1 | FBpp0081910 | FBpp0086223 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.912 |
| Blm | Pif1 | FBpp0081910 | FBpp0309921 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. | 0.881 |
| Blm | RecQ4 | FBpp0081910 | FBpp0076452 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | RecQ4 helicase (RecQ4) encodes an important protein for genome stability and DNA metabolism. It can utilize energy from ATP hydrolysis to help the DNA strand separation and exchange, playing a critical role in replication and repair. | 0.539 |
| Blm | RpA-70 | FBpp0081910 | FBpp0081356 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.997 |
| Blm | mus81 | FBpp0081910 | FBpp0070165 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | EG:BACR7A4.16 protein; Mus81 (mus81) encodes the catalytic subunit of the Mus81-mms4 structure-selective endonuclease that functions in DNA repair. | 0.988 |
| Blm | tos | FBpp0081910 | FBpp0080675 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | Exonuclease 1; 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity). | 0.982 |
| CG2990 | Blm | FBpp0071350 | FBpp0081910 | FI06813p; 5'-flap endonuclease activity; RNA binding. It is involved in the biological process described with: DNA replication, Okazaki fragment processing; replication fork reversal. | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | 0.928 |
| CG2990 | Cdc45 | FBpp0071350 | FBpp0070175 | FI06813p; 5'-flap endonuclease activity; RNA binding. It is involved in the biological process described with: DNA replication, Okazaki fragment processing; replication fork reversal. | CDC45L (CDC45L) encodes a protein that contributes to 3'-5' DNA helicase activity of the Cdc45/Mcm2-7/GINS complex. It is involved in chromosome condensation and the regulation of the mitotic G1/S transition. | 0.934 |
| CG2990 | Ctf4 | FBpp0071350 | FBpp0086732 | FI06813p; 5'-flap endonuclease activity; RNA binding. It is involved in the biological process described with: DNA replication, Okazaki fragment processing; replication fork reversal. | Chromosome transmission fidelity 4; Chromatin binding. | 0.994 |
| CG2990 | DNApol-delta | FBpp0071350 | FBpp0075277 | FI06813p; 5'-flap endonuclease activity; RNA binding. It is involved in the biological process described with: DNA replication, Okazaki fragment processing; replication fork reversal. | DNA polymerase delta catalytic subunit; As the catalytic component of the DNA polymerase delta complex, plays a crucial role in high fidelity genome replication, including lagging strand synthesis, DNA recombination and repair (By similarity). Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Required at the nucleus of rapidly dividing embryonic cells to activate genome replication during the earliest cell cycles. Likely to require the presence of accessory proteins Pol31 and Pol32 for full activity. | 0.951 |
| CG2990 | Fen1 | FBpp0071350 | FBpp0086223 | FI06813p; 5'-flap endonuclease activity; RNA binding. It is involved in the biological process described with: DNA replication, Okazaki fragment processing; replication fork reversal. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.995 |
| CG2990 | Pif1 | FBpp0071350 | FBpp0309921 | FI06813p; 5'-flap endonuclease activity; RNA binding. It is involved in the biological process described with: DNA replication, Okazaki fragment processing; replication fork reversal. | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. | 0.930 |
| CG2990 | RecQ4 | FBpp0071350 | FBpp0076452 | FI06813p; 5'-flap endonuclease activity; RNA binding. It is involved in the biological process described with: DNA replication, Okazaki fragment processing; replication fork reversal. | RecQ4 helicase (RecQ4) encodes an important protein for genome stability and DNA metabolism. It can utilize energy from ATP hydrolysis to help the DNA strand separation and exchange, playing a critical role in replication and repair. | 0.968 |
| CG2990 | RpA-70 | FBpp0071350 | FBpp0081356 | FI06813p; 5'-flap endonuclease activity; RNA binding. It is involved in the biological process described with: DNA replication, Okazaki fragment processing; replication fork reversal. | Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.971 |
| CG2990 | mus81 | FBpp0071350 | FBpp0070165 | FI06813p; 5'-flap endonuclease activity; RNA binding. It is involved in the biological process described with: DNA replication, Okazaki fragment processing; replication fork reversal. | EG:BACR7A4.16 protein; Mus81 (mus81) encodes the catalytic subunit of the Mus81-mms4 structure-selective endonuclease that functions in DNA repair. | 0.942 |
| CG2990 | tos | FBpp0071350 | FBpp0080675 | FI06813p; 5'-flap endonuclease activity; RNA binding. It is involved in the biological process described with: DNA replication, Okazaki fragment processing; replication fork reversal. | Exonuclease 1; 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity). | 0.998 |
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