Egfr protein (fruit fly) - STRING interaction network
"Egfr" - Epidermal growth factor receptor in Drosophila melanogaster
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
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Gene Fusion
EgfrEpidermal growth factor receptor; Binds to four ligands- Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf- MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and productio [...] (1426 aa)    
Predicted Functional Partners:
Protein enhancer of sevenless 2B; Required for proper signaling by sevenless. May act to stimulate the ability of Sos to catalyze Ras1 activation by linking sevenless and Sos in a signaling complex; Belongs to the GRB2/sem-5/DRK family (211 aa)
Cbl proto-oncogene (Cbl) is an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After Cbl-mediated ubiquitination, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation (878 aa)
Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis (189 aa)
Protein spitz; Ligand for the EGF receptor (Gurken). Involved in a number of unrelated developmental choices, for example, dorsal- ventral axis formation, glial migration, sensory organ determination, and muscle development. It is required for photoreceptor determination (234 aa)
SHC-adaptor protein; It is involved in the biological process described with- epidermal growth factor receptor signaling pathway; melanotic encapsulation of foreign target; tracheal outgrowth, open tracheal system; torso signaling pathway; TORC1 signaling (409 aa)
Protein giant-lens; Regulates cell determination; development of ommatidia and optic lobe. Is a signaling molecule involved in the process of axon pathfinding in the eye. Part of the Ras pathway regulating programmed cell death in pupal eyes; activated by lozenge (lz). Antagonist for the Egfr receptor (gurken). Inhibits Egfr signaling without interacting directly with the receptor, but instead by sequestering the Egfr-activating ligand spitz (spi) (444 aa)
Protein son of sevenless; Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development (1596 aa)
Protein sprouty; Inhibitor of tracheal branching that restricts branch budding by antagonizing the BNL-FGF pathway (BNL- branchless, an fgf inducer of branching). Acts as an antagonist of EGFR-mediated signaling in the eye (where it is important for cell determination) midline glia, chordotonal organs, wing and ovarian follicle cells (589 aa)
Protein gurken; Critical for defining the anterior-posterior and dorsal- ventral axes of the egg. May signal directly to dorsal follicle cells through the receptor torpedo (top). During oogenesis this signaling pathway instructs follicle cells to follow a dorsal pathway of development rather than the default ventral pathway (295 aa)
Protein vein; Ligand for the EGF receptor. Seems to play a role in the global proliferation of wing disc cells and the larval patterning. Shows a strong synergistic genetic interaction with spi, suggesting a molecular interdependence. Required for the development of interveins cells (623 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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