STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LBRLamin-B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane; Belongs to the ERG4/ERG24 family. (741 aa)    
Predicted Functional Partners:
LamC
Lamin-C; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin (By similarity). In spermatocytes, regulates cytokinesis during meiosis.
   
 
 0.995
Su(var)205
Heterochromatin protein 1; Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.
   
 
 0.992
CG7724
GH25466p; Oxidoreductase activity; 3-beta-hydroxy-delta5-steroid dehydrogenase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; steroid delta-isomerase activity. It is involved in the biological process described with: oxidation-reduction process; steroid biosynthetic process; Belongs to the 3-beta-HSD family.
   
 
 0.989
Lam
Lamin Dm0; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. May have a role in the localization of the LEM domain proteins Ote, bocks and MAN1 to the nuclear membrane. In spermatocytes, plays a role in maintaining type-A lamin LamC nuclear localization; regulates meiotic cytokinesis by maintaining the structure of the spindle envelope, and by contributing to the formation of the contractile ring and central spindle.
   
 
 0.983
baf
Barrier-to-autointegration factor; Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Functions are required in both M phase and interphase of the cell cycle. Belongs to the BAF family.
   
  
 0.962
MAN1
Inner nuclear membrane protein Man1; Inner nuclear membrane protein. Acts as a negative regulator of the BMP (Dpp) signaling cascade during crossvein development in pupal wings and possibly during synaptic transmission at the neuromuscular junction (NMJ). Appears to be required for pupal development and consequently transition to the adult stage. During pupal development, plays essential and redundant functions with the other LEM domain proteins; bocks and Ote.
   
  
 0.953
CG17270
GM10285p; Protein-macromolecule adaptor activity.
   
 
 0.930
CG1998
RE26969p; Iron ion binding; oxidoreductase activity; C-4 methylsterol oxidase activity. It is involved in the biological process described with: sterol biosynthetic process; oxidation-reduction process; Belongs to the sterol desaturase family.
   
 
 0.925
CG11162
Fatty acid hydroxylase domain-containing protein; C-4 methylsterol oxidase activity; oxidoreductase activity; iron ion binding. It is involved in the biological process described with: sterol biosynthetic process; oxidation-reduction process; Belongs to the sterol desaturase family.
   
 
 0.921
CG5854
LD23561p; Catalytic activity; coenzyme binding.
   
 
 0.876
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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