STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG11275FI01029p; Ubiquitin protein ligase binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of proteolysis. (417 aa)    
Predicted Functional Partners:
rdx
Protein roadkill; Involved in segment polarity. In complex with gft/CUL3, promotes ubiquitination of ci and its subsequent degradation by the proteasome, which results in hh signaling attenuation. This regulation may be important during eye formation for proper packing of ommatidia into a hexagonal array.
     
 
0.800
CG11474
LD03212p; Phosphatase activity; protein carboxyl O-methyltransferase activity. It is involved in the biological process described with: regulation of response to DNA damage stimulus.
      
 0.670
CG13631
GEO09349p1.
      
 0.666
CG5554
Uncharacterized protein, isoform B; Disulfide oxidoreductase activity. It is involved in the biological process described with: cell redox homeostasis.
      
 0.653
CG7637
H/ACA ribonucleoprotein complex subunit 3; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity); Belongs to the NOP10 family.
      
 0.627
whe
What else, isoform A.
    
 
 0.623
CG11147
RH61964p; ATPase activity; ATP binding. It is involved in the biological process described with: transmembrane transport.
      
 0.607
msb1l
LD32040p.
      
 0.604
CG15098
LP21121p.
      
 0.600
Cul3
Cullin 3, isoform F; Ubiquitin protein ligase binding; molecular adaptor activity; ubiquitin-protein transferase activity; protein binding; Belongs to the cullin family.
    
 0.561
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.