STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dveDefective proventriculus (dve) encodes a transcriptional repressor that binds to the K50 site. It is involved in developmental patterning, cell-type specification, and functional differentiation. (1024 aa)    
Predicted Functional Partners:
ATbp
AT-rich binding protein; May be a transcription factor for genes having (A+T) stretches in their promoter and/or enhancer regions. Binds to AT rich DNA.
    
 
 0.843
ubl
Ubiquitin-like protein 5; Protein tag. It is involved in the biological process described with: mRNA splicing, via spliceosome; cellular protein modification process.
    
 
 0.790
ClpP
ATP-dependent Clp protease proteolytic subunit; ATP-dependent peptidase activity; ATPase binding; serine-type endopeptidase activity. It is involved in the biological process described with: protein quality control for misfolded or incompletely synthesized proteins; proteolysis involved in cellular protein catabolic process; regulation of mitochondrial gene expression.
      
 0.726
oc
Homeotic protein ocelliless; Transcriptional regulator involved in pattern formation and cell determination in the embryonic CNS and larval imaginal disks. Also later in development to coordinate the expression of regulatory and structural genes required for photoreceptor cell fate in the ocelli. Has a dual role in the terminal differentiation of subtypes of photoreceptors by regulating rhodopsin (rh) expression: essential for establishing the expression of rh genes in the pale subset of ommatidia as well as repressing Rh6 in outer photoreceptors. Belongs to the paired homeobox family.
      
 0.686
Pph13
PvuII-PstI homology 13 (Pph13) encodes a paired-class homeodomain protein. It is critical for rhabdomeric photoreceptor differentiation, phototransduction and rhabdomere morphogenesis.
    
 
 0.682
Rh3
Rhodopsin 3 (Rh3) encodes a Rhodopsin GPCR protein that responds to UV light and activates the phototransduction cascade that leads to photoreceptor depolarization. Rh3 is expressed in R7 photoreceptors in a stochastic manner: 35% of R7 photoreceptors express Rh3 while the remaining 65% express another UV-sensitive Rhodopsin encoded by Rh4.
      
 0.669
Rh5
Rhodopsin 5 (Rh5) encodes a visual GPCR opsin that covalently binds the chromophore retinal. A photon of light stimulates the isomerization of retinal resulting in a conformational change in the product of Rh5 and signal activation. Its peak sensitivity is in the blue and it is expressed in a subclass of R8 photoreceptors; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
      
 0.664
Rh4
Opsin Rh4; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
      
 0.663
Rh6
Opsin Rh6; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
      
 0.661
CTCF
GH14774p; CTCF (CTCF) encodes a ubiquitous transcription factor that binds to insulators and domain boundaries. It mediates insulator function and blocks enhancers by binding to the product of Cp190. It contributes to long-range chromatin interaction, organizes chromatin domain boundaries and coordinates nuclear architecture.
    
 
 0.614
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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