STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
T3dhProbable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. (464 aa)    
Predicted Functional Partners:
Fdh
Alcohol dehydrogenase class-3; Formaldehyde dehydrogenase (Fdh) encodes a medium-chain alcohol dehydrogenase. This enzyme also functions as S-nitrosoglutathione reductase during the nitric oxide metabolism, contributing to visual memory.
  
 
 0.992
Aldh-III
Aldehyde dehydrogenase type III (Aldh-III) encodes a protein that confers a xenobiotic stress resistance by oxidising aromatic aldehydes (benzaldehyde). It also neutralises the lipid aldehydes formed after the attack of reactive oxygen and radicals, such as malondialdehyde during lipid peroxidation. The catalytic redox reaction uses NAD(P)+ as a cofactor.
 
 
 0.798
L2HGDH
L-2-hydroxyglutarate dehydrogenase, isoform A; (S)-2-hydroxy-acid oxidase activity; 2-hydroxyglutarate dehydrogenase activity. It is involved in the biological process described with: oxidation-reduction process.
     
 0.743
Eno
Enolase (Eno) encodes a phosphopyruvate hydratase involved in glucose homeostasis; Belongs to the enolase family.
  
 
 0.736
CG7920
GM14349p; Catalytic activity. It is involved in the biological process described with: acetyl-CoA metabolic process.
  
  
 0.731
TBCD
Tubulin folding cofactor D (TBCD) encodes one of the tubulin folding cofactors, which assist in the formation of tubulin heterodimers. It cooperates with the product of Dscam1 to regulate microtubule organization during neural development.
  
  
 0.729
Pfk
ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
  
  
 0.721
Hacl
Magnesium ion binding; carbon-carbon lyase activity; thiamine pyrophosphate binding. It is involved in the biological process described with: fatty acid alpha-oxidation; Belongs to the TPP enzyme family.
  
  
 0.716
CG5044
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.
  
 
 0.713
CG17896
Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity).
 
 
 
 0.691
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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