STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
wdpProtein windpipe; Plays a role in negative regulation of the JAK/STAT pathway by binding to the receptor dome and promoting its internalization for subsequent lysosomal degradation, thereby reducing JAK/STAT signaling. (677 aa)    
Predicted Functional Partners:
FBgn0261842
Pre-mod(Mdg4)-AE, isoform A.
      
 0.791
CG7058
GH01369p; Ubiquitin protein ligase binding. It is involved in the biological process described with: regulation of proteolysis; ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process.
      
 0.680
Cirl
Latrophilin Cirl; Latrotoxin receptor activity; G protein-coupled receptor activity; carbohydrate binding; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
    
   0.636
lili
Lilipod (lili) encodes a multi-pass transmembrane protein required for Dpp signal transduction in the female germline to promote ovarian stem cell maintenance; Belongs to the LIMR family.
      
 0.630
CG8708
RE41083p; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity; beta-1,3-galactosyltransferase activity. It is involved in the biological process described with: O-glycan processing, core 1; protein glycosylation.
      
 0.602
SclA
Sarcolamban A; Plays an essential role in the regulation of calcium transport at the sarcoplasmic reticulum (SR), which is secondarily required for regular muscle contraction.
      
 0.600
dome
Cytokine receptor; Critical for epithelial morphogenesis during oogenesis; border cell migration. Required in the germarium for the polarization of follicle cells during encapsulation of germline cells. Required for embryonic segmentation and trachea specification. Essential receptor molecule for upd and JAK/STAT signaling during oogenesis.
    
 
 0.578
wat
Fatty acyl-CoA reductase wat; Catalyzes the reduction of saturated fatty acyl-CoA to fatty alcohols. The preferred substrates are C24:0 and C26:0. Necessary for the final stages of tracheal maturation, to facilitate the transition from water-filled to gas-filled tubes. May help to maintain the integrity of the outer hydrophobic envelope of the trachea.
   
  
 0.536
CG34460
SVWC domain-containing protein.
      
 0.532
MESR4
Misexpression suppressor of ras 4 (MESR4) encodes a plant homeodomain finger protein required for proper activation of the EGFR signaling pathway. It contributes to innate immunity, cellular response to hypoxia, regulation of fat storage, and embryonic development.
    
 
 0.525
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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