STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Golgin245Golgin-245; Rab GTPase binding; ADP-ribosylation factor binding. It is involved in the biological process described with: Golgi vesicle transport. (1489 aa)    
Predicted Functional Partners:
Arl1
ADP-ribosylation factor-like protein 1; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
    
 0.911
cbs
Centrosomin's beautiful sister (cbs) encodes a a Golgi protein required for the centrosome cycle.
   
 
 0.901
GCC88
GRIP and coiled-coil domain containing 88 kDa; ADP-ribosylation factor binding; Rab GTPase binding. It is involved in the biological process described with: Golgi vesicle transport.
     
 0.890
GCC185
GRIP and coiled-coil domain containing 185 kDa; Identical protein binding; ADP-ribosylation factor binding; Rab GTPase binding.
   
 
 0.851
GM130
Golgi matrix protein 130 kD (GM130) encodes a protein involved in Golgi compartmental organization and regulation of dendrite morphogenesis.
   
  
 0.850
Gmap
Golgi microtubule-associated protein (Gmap) encodes a peripheral Golgi protein that is required for the efficient trafficking within the early secretory pathway, probably by recruiting Rab proteins and effector molecules.
   
  
 0.847
Rab6
Ras-related protein Rab6; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Mediates membrane trafficking during egg chamber growth and organization, possibly upstream of exocyst component Sec5. Also during oogenesis, plays a role, together with BicD but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in the localization of oskar mRNA and in the anterodorsal secretion of grk. Required for anterograde opsin transport through the ER-Golgi complex. Plays a role, together with Rich, in regula [...]
   
 
 0.764
Rab30
Rab30, isoform A; Rab30 (Rab30) encodes a JNK transcriptional target. It is involved in JNK-mediated processes such as dorsal closure, embryonic head involution and thorax closure.
    
 
 0.756
Rich
Guanine nucleotide exchange factor subunit Rich; Probable component of a guanine nucleotide exchange factor (GEF) that may be required for efficient fusion of endosome-derived vesicles with the Golgi (By similarity). Plays a role in regulating Rab6-dependent CadN transport in photoreceptor cells which is required for the formation of normal synaptic connections between axons from the inner photoreceptor cells in the eye and postsynaptic cells in the brain medulla layer M6, and for the generation of normal postsynaptic responses.
   
 
 0.720
Vps52
Vacuolar protein sorting 52; Rab GTPase binding; syntaxin binding. It is involved in the biological process described with: retrograde transport, endosome to Golgi; lysosomal transport; Golgi to vacuole transport; endocytic recycling.
   
 
 0.712
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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