Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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co-expression
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[Homology]
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angelProtein angel; 3'-5'-exoribonuclease activity; Belongs to the CCR4/nocturin family. (354 aa)    
Predicted Functional Partners:
CG1620
Uncharacterized protein, isoform A; RNA polymerase II repressing transcription factor binding; histone deacetylase binding; transcription corepressor activity; DNA binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II.
   
  
 0.749
PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...]
      
 0.723
CG30183
Uncharacterized protein, isoform A; Actin binding; GTP-Rho binding. It is involved in the biological process described with: protein localization to mitotic actomyosin contractile ring; actomyosin contractile ring assembly; septin ring organization; mitotic cytokinesis; cortical cytoskeleton organization.
    
 
 0.667
CG15571
GEO10373p1; It is involved in the biological process described with: eggshell chorion assembly.
      
 0.599
CG13114
IP19013p.
      
 0.599
CG13084
Uncharacterized protein.
      
 0.597
PAN3
PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...]
      
 0.582
CG7156
LD24550p; Protein serine/threonine kinase activity; phosphatidylinositol binding; ATP binding. It is involved in the biological process described with: protein phosphorylation.
   
  
 0.576
RtcB
RNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs; Belongs to the RtcB family.
   
  
 0.564
l(2)dtl
Protein lethal(2)denticleless; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of E2f during S phase. E2f degradation is necessary to ensure proper development. Substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, leading to recruit the DCX(DTL) complex; Belongs to the WD repeat cdt2 family.
   
  
 0.539
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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