Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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sigmarTumor necrosis factor alpha-induced protein 8-like protein; Salivary glands marred (sigmar) encodes a TNFAIP8-like (TIPE) protein family member. Its expression levels are responsive to the TNF ligand encoded by egr. The product of sigmar contribute to JNK signaling modulation, cytoskeletal remodeling and autophagy. (210 aa)    
Predicted Functional Partners:
Paics
Phosphoribosylaminoimidazole-succinocarboxamide synthase; PAICS bifunctional enzyme (Paics) encodes an essential enzyme in the pathway for de novo synthesis of the purine nucleotide inosine monophosphate (IMP). IMP is the precursor for purine nucleotides required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the N-terminal section; belongs to the SAICAR synthetase family.
    
   0.856
Fbw5
F-box and WD repeat domain containing 5 (Fbw5) encodes a protein that targets proteins for destruction via its role as a substrate receptor for the CRL4 E3 ubiquitin ligase. A key target of the product of Fbw5 is the subunit of the tuberous sclerosis complex encoded by gig, an important negative regulator of cellular growth via inhibition of the TOR kinase pathway.
      
 0.758
CG5550
Uncharacterized protein, isoform B.
      
 0.653
CG16775
DUF3421 domain-containing protein.
      
 0.651
Map205
Microtubule-associated protein 205 (Map205) encodes a protein that binds and stabilizes microtubules. It also binds, inhibits and stabilizes the product of polo on microtubules during interphase.
   
  
 0.614
CG4607
RH58543p; Carbohydrate:proton symporter activity. It is involved in the biological process described with: glucose import; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
      
 0.598
CG7248
FI02047p; Chitin binding. It is involved in the biological process described with: chitin metabolic process.
   
  
 0.598
CG4743
S-adenosylmethionine mitochondrial carrier protein homolog; Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May mediate the transport of S-adenosylmethionine (SAM) into the mitochondria (By similarity).
      
 0.597
CG18004
FI20187p1; It is involved in the biological process described with: chromatin remodeling.
      
 0.589
Traf-like
TNF-receptor-associated factor-like, isoform A; Protein binding. It is involved in the biological process described with: positive regulation of lipophagy.
    
   0.557
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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