STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppk3Pickpocket 3; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (535 aa)    
Predicted Functional Partners:
Ehbp1
Eps15 homology domain containing protein-binding protein 1 (Ehbp1) encodes a protein that mediates asymmetric protein secretion. It regulates the trafficking and secretion of distinct Notch signaling components and extracellular membrane proteins.
      
 0.430
ppk6
Pickpocket 6 (ppk6) encodes a member of the DEG/ENaC family, whose members act as non-voltage-gated cation channels. DEG/ENaC family members have been implicated in the maintenance of sodium gradients across epithelial membranes, as well as in diverse sensory modalities, which include gustatory chemosensation, mechanosensation, hygrosensation, and nociception; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
  
   
 0.422
aux
Auxilin, isoform A; Auxilin (aux) encodes a co-factor for the ATPase Hsc70 that regulates Clathrin dynamics. It regulates Notch signaling, eye morphogenesis, sperm individualization and neuron death.
      
 0.414
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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