Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Ak2Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways; Belongs to the adenylate kinase family. AK2 subfamily. (240 aa)    
Predicted Functional Partners:
AMPdeam
AMP deaminase activity. It is involved in the biological process described with: IMP biosynthetic process; IMP salvage; AMP metabolic process; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
   
 
 0.981
Ak6
Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP is the best phosphate acceptor, and CMP is also a good substrate. All nucleoside triphosphates ATP, TTP, CTP, GTP, and UTP are accepted as phosphate donors. ATP is the best phosphate donor. May have a role in nuclear energy homeostasis; Belongs to the adenylate kinase family. AK6 subfamily.
   
 
 0.980
Aprt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 0.970
Adk2
Adenosine kinase activity. It is involved in the biological process described with: purine ribonucleoside salvage; AMP biosynthetic process.
  
 0.963
Adk1
AT16233p; Adenosine kinase activity. It is involved in the biological process described with: purine ribonucleoside salvage; AMP biosynthetic process.
  
 0.961
Adk3
GM02629p; Adenosine kinase activity.
  
 0.961
Ak1
ATP binding; adenylate kinase activity; uridylate kinase activity; Belongs to the adenylate kinase family.
  
0.956
AdSL
Adenylosuccinate Lyase (AdSL) encodes a protein that might be a lyase involved in purine nucleotide metabolic process based on orthology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
   
 0.951
dnc
Dunce (dnc) encodes a cAMP-specific phosphodiesterase, responsible for cAMP degradation. dnc product plays a pivotal role in neurological and behavioral plasticity including synaptic development and function, learning and courtship. The product of dnc is also known to affect regulation of several developmental processes such as oogenesis; Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
     
 0.947
Pde11
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
     
 0.947
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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