Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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Zfrp8Zinc finger protein RP-8 (Zfrp8) encodes a highly conserved protein essential for stem cell maintenance and fast proliferating cells such as cancer cells. It functions in the formation of mRNA ribonucleoprotein (mRNP) complexes. It may regulate the binding of specific mRNPs to the small ribosomal subunit, ultimately controlling their cytoplasmic localization and translation. (347 aa)    
Predicted Functional Partners:
RpS2
Ribosomal protein S2 (RpS2) encodes a highly conserved component of the 40S ribolomal comlex. RpS2 product controls the assembly and nuclear export of the pre-ribosome and appears to have a specific function during oogenesis.
   
 
 0.977
Nufip
Nufip (Nufip) encodes an adaptor protein for the assembly of RiboNucleo-Particles (RNPs) such as the small nuclear RNP U4 (snRNP U4; part of the spliceosome) and the mRNPs encoding seleno-proteins. It is necessary for the biogenesis of the small nucleolar RNPs (snoRNPs).
   
 
 0.786
CG3603
RH09070p; Estradiol 17-beta-dehydrogenase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; 3-hydroxyacyl-CoA dehydrogenase activity; quinone binding. It is involved in the biological process described with: oxidation-reduction process; fatty acid biosynthetic process.
    
 
 0.786
CG9286
Protein BCCIP homolog; Protein kinase regulator activity; tubulin binding; kinase regulator activity; Belongs to the BCP1 family.
   
  
 0.776
CG9890
LD46465p; Nucleic acid binding.
   
 
 0.768
bys
Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family.
   
  
 0.758
LTV1
Protein LTV1 homolog; LTV1 ribosome biogenesis factor (LTV1) encodes a protein involved in pre-rRNA processing that is required for the proper biogenesis of the 40S ribosome. LTV1 product is a direct transcriptional target of Myc, thus it is critical for cell growth and survival.
   
  
 0.753
mael
Protein maelstrom; Involved both in the piRNA and miRNA metabolic processes. As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons. As a nuclear component, it is required for proper differentiation in t [...]
    
 
 0.671
Prosbeta6
Proteasome subunit beta type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; Belongs to the peptidase T1B family.
      
 0.651
Fmr1
Synaptic functional regulator FMR1; Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs. Plays a role as a negative translational regulator of specific mRNAs. Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function. May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC). Required for stability of the central pair of microtubule [...]
    
 
 0.634
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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