STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bsSerum response factor homolog; Required for the formation of intervein tissue of the wing. Acts in a dosage-dependent manner to suppress wing vein formation and promote development of intervein cells. Might play a role in the proper formation and maintenance of the trachea. (449 aa)    
Predicted Functional Partners:
Mrtf
Myocardin-related transcription factor (Mrtf) encodes a protein that binds to the product of bs, and likely other transcription factors, to enhance downstream gene activation. The activity of the product of Mrtf is regulated by free actin levels. It contributes to tracheal branching, border cell migration, and other cell stretching and invasive migration processes during development.
    
 0.997
mys
Integrin beta-PS; Integrin alpha-PS1/beta-PS is a receptor for laminin. Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not. Required for rhea/talin correct cellular localization in the midgut. Required for m [...]
    
 
 0.779
sd
Scalloped, isoform Q; Scalloped (sd) encodes a DNA binding protein of the TEAD class. It requires co-factor proteins ,such as the products of vg and yki, to act as a transcription factor, and is modified by Hippo and Wingless signalling. It is involved in wing and neuronal specification.
    
 
 0.716
tin
Muscle-specific homeobox protein tinman; Required for the development of heart and visceral muscle; for the formation of somatic muscles. Has a crucial function in the early mesodermal subdivisions.
    
 
 0.676
pnr
GATA-binding factor A; Transcriptional regulator involved in several developmental processes during embryonic and imaginal disks development. Involved in determining dorsal cell fate. Acts as an essential transcriptional regulator of proneural achaete-scute complex (AS-C) and is required for its spatial regulation during development of the adult peripheral nervous system, and hence for the positioning of neural precursors. It is the only factor to directly activate AS-C genes.
    
 
 0.669
rho
Protein rhomboid; Acts early in embryonic development to establish position along the dorsoventral axis and then again later to specify the fate of neuronal precursor cells. Involved in EGF receptor signaling; cleaves Spitz to release the active growth factor. Belongs to the peptidase S54 family.
    
 
 0.649
Utx
Utx histone demethylase (Utx) encodes a Jumonji C containing protein that catalyzes the removal of methyl groups from Histone H3 lysine 27. Together with the products of trr and Lpt, it is thought to regulate chromatin structure at transcriptional enhancers.
   
 
 0.612
mirr
Mirror, isoform C; Mirror (mirr) encodes an iroquois homeobox transcription factor involved in dorso-ventral axis formation during oogenesis and eye formation. It also contributes to embryonic segmentation, peripheral nervous system development and growth regulation.
   
 
 0.584
HDAC4
Histone deacetylase 4, isoform G; Histone deacetylase 4 (HDAC4) encodes a Class IIa histone deacetylase that modulates gene expression by associating with transcriptional factors. It is regulated by nucleocytoplasmic shuttling and contributes to embryogenesis, muscle development, circadian function, energy balance and memory.
    
 
 0.582
nau
Nautilus (nau) encodes a protein that belongs to the bHLH family of transcription factors. It is the unique Drosophila ortholog of the mammalian family of bHLH Myogenic Regulatory Factors. It is involved in somatic muscle myogenesis.
   
 
 0.577
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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