STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG3483CG3483 protein; Isocitrate dehydrogenase (NAD+) activity. It is involved in the biological process described with: isocitrate metabolic process; tricarboxylic acid cycle. (391 aa)    
Predicted Functional Partners:
Idh
Isocitrate dehydrogenase (Idh) encodes a cytosolic enzyme that catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate, with the concomitant reduction of NADP[+] to NADPH. It functions, along with Men, Zw, and Pgd, in a small network of NADP reducing enzymes.
  
 0.983
CG7755
FI08254p1; Isocitrate dehydrogenase (NAD+) activity. It is involved in the biological process described with: isocitrate metabolic process; tricarboxylic acid cycle.
  
 
0.969
mAcon2
Aconitate hydratase, mitochondrial; 4 iron, 4 sulfur cluster binding; aconitate hydratase activity. It is involved in the biological process described with: tricarboxylic acid cycle; multicellular organism reproduction; Belongs to the aconitase/IPM isomerase family.
  
 0.944
Nc73EF
Neural conserved at 73EF, isoform I; Oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding. It is involved in the biological process described with: tricarboxylic acid cycle.
  
 0.939
CG5028
RH49423p; Isocitrate dehydrogenase (NAD+) activity. It is involved in the biological process described with: tricarboxylic acid cycle; isocitrate metabolic process.
  
 
0.933
Idh3b
Isocitrate dehydrogenase 3b (Idh3b) encodes a mitochondrial enzyme of the tricarboxylic acid cycle involved in salivary gland cell autophagy.
  
 
0.932
CG9674
Uncharacterized protein, isoform F; It is involved in the biological process described with: glutamate biosynthetic process; ammonia assimilation cycle; oxidation-reduction process.
  
 
 0.899
bb8
Big bubble 8 (bb8) encodes a glutamate dehydrogenase involved in the development of the spermatid mitochondria; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.894
mAcon1
Aconitate hydratase, mitochondrial; Mitochondrial aconitase 1 (mAcon1) encodes an enzyme that harbors an iron-sulfur cluster and catalyses the first step of the Krebs Cycle in mitochondria, converting citrate into isocitrate; Belongs to the aconitase/IPM isomerase family.
  
 0.891
CG3492
GH18016p; Peptidyl-prolyl cis-trans isomerase activity; cyclosporin A binding. It is involved in the biological process described with: protein folding; protein peptidyl-prolyl isomerization.
  
  
 0.889
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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