node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EMRE | Letm1 | FBpp0085960 | FBpp0072255 | Essential MCU regulator, mitochondrial; Essential regulatory subunit of the mitochondrial calcium uniporter MCU channel, a protein that mediates calcium uptake into mitochondria. | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion. Belongs to the LETM1 family. | 0.795 |
EMRE | MCU | FBpp0085960 | FBpp0300166 | Essential MCU regulator, mitochondrial; Essential regulatory subunit of the mitochondrial calcium uniporter MCU channel, a protein that mediates calcium uptake into mitochondria. | Calcium uniporter protein, mitochondrial; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore- forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Together with Itpr, has a role in oxidative stress-induced ER-mitochondria calcium transfer. During pupation, required for memory function in mushroom body neurons. Belongs to the MCU (TC 1.A.77) family. | 0.998 |
EMRE | MICU1 | FBpp0085960 | FBpp0111941 | Essential MCU regulator, mitochondrial; Essential regulatory subunit of the mitochondrial calcium uniporter MCU channel, a protein that mediates calcium uptake into mitochondria. | Calcium uptake protein 1 homolog, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (Probable). During development, required in alpha/beta or gamma mushroom body neurons to support olfactory intermediate-term memory in the adult ; Belongs to the MICU1 family. MICU1 subfamily. | 0.999 |
Letm1 | EMRE | FBpp0072255 | FBpp0085960 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion. Belongs to the LETM1 family. | Essential MCU regulator, mitochondrial; Essential regulatory subunit of the mitochondrial calcium uniporter MCU channel, a protein that mediates calcium uptake into mitochondria. | 0.795 |
Letm1 | MCU | FBpp0072255 | FBpp0300166 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion. Belongs to the LETM1 family. | Calcium uniporter protein, mitochondrial; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore- forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Together with Itpr, has a role in oxidative stress-induced ER-mitochondria calcium transfer. During pupation, required for memory function in mushroom body neurons. Belongs to the MCU (TC 1.A.77) family. | 0.874 |
Letm1 | MICU1 | FBpp0072255 | FBpp0111941 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion. Belongs to the LETM1 family. | Calcium uptake protein 1 homolog, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (Probable). During development, required in alpha/beta or gamma mushroom body neurons to support olfactory intermediate-term memory in the adult ; Belongs to the MICU1 family. MICU1 subfamily. | 0.934 |
Letm1 | OXA1L | FBpp0072255 | FBpp0076000 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion. Belongs to the LETM1 family. | OXA1L mitochondrial inner membrane protein, isoform A; Membrane insertase activity. It is involved in the biological process described with: protein insertion into mitochondrial inner membrane from matrix; mitochondrial cytochrome c oxidase assembly; respiratory chain complex IV assembly; protein insertion into membrane. | 0.764 |
Letm1 | RpL11 | FBpp0072255 | FBpp0309436 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion. Belongs to the LETM1 family. | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 0.728 |
Letm1 | RpL23 | FBpp0072255 | FBpp0071808 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion. Belongs to the LETM1 family. | 60S ribosomal protein L23; Large ribosomal subunit rRNA binding; structural constituent of ribosome; myosin binding. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the universal ribosomal protein uL14 family. | 0.728 |
Letm1 | RpS11 | FBpp0072255 | FBpp0087115 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion. Belongs to the LETM1 family. | 40S ribosomal protein S11; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the universal ribosomal protein uS17 family. | 0.728 |
Letm1 | RpS18 | FBpp0072255 | FBpp0085585 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion. Belongs to the LETM1 family. | Ribosomal protein S18 (RpS18) encodes a ribosomal protein located at the top of the head of the 40S subunit and contacts several helices of the 18S rRNA. | 0.728 |
Letm1 | RpS9 | FBpp0072255 | FBpp0309532 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion. Belongs to the LETM1 family. | Ribosomal protein S9 (RpS9) encodes a structural constituent of ribosomes. | 0.732 |
Letm1 | mRpL45 | FBpp0072255 | FBpp0083665 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion. Belongs to the LETM1 family. | Probable 39S ribosomal protein L45, mitochondrial; Structural constituent of ribosome. It is involved in the biological process described with: mitochondrial translation. | 0.767 |
MCU | EMRE | FBpp0300166 | FBpp0085960 | Calcium uniporter protein, mitochondrial; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore- forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Together with Itpr, has a role in oxidative stress-induced ER-mitochondria calcium transfer. During pupation, required for memory function in mushroom body neurons. Belongs to the MCU (TC 1.A.77) family. | Essential MCU regulator, mitochondrial; Essential regulatory subunit of the mitochondrial calcium uniporter MCU channel, a protein that mediates calcium uptake into mitochondria. | 0.998 |
MCU | Letm1 | FBpp0300166 | FBpp0072255 | Calcium uniporter protein, mitochondrial; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore- forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Together with Itpr, has a role in oxidative stress-induced ER-mitochondria calcium transfer. During pupation, required for memory function in mushroom body neurons. Belongs to the MCU (TC 1.A.77) family. | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion. Belongs to the LETM1 family. | 0.874 |
MCU | MICU1 | FBpp0300166 | FBpp0111941 | Calcium uniporter protein, mitochondrial; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore- forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Together with Itpr, has a role in oxidative stress-induced ER-mitochondria calcium transfer. During pupation, required for memory function in mushroom body neurons. Belongs to the MCU (TC 1.A.77) family. | Calcium uptake protein 1 homolog, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (Probable). During development, required in alpha/beta or gamma mushroom body neurons to support olfactory intermediate-term memory in the adult ; Belongs to the MICU1 family. MICU1 subfamily. | 0.998 |
MICU1 | EMRE | FBpp0111941 | FBpp0085960 | Calcium uptake protein 1 homolog, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (Probable). During development, required in alpha/beta or gamma mushroom body neurons to support olfactory intermediate-term memory in the adult ; Belongs to the MICU1 family. MICU1 subfamily. | Essential MCU regulator, mitochondrial; Essential regulatory subunit of the mitochondrial calcium uniporter MCU channel, a protein that mediates calcium uptake into mitochondria. | 0.999 |
MICU1 | Letm1 | FBpp0111941 | FBpp0072255 | Calcium uptake protein 1 homolog, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (Probable). During development, required in alpha/beta or gamma mushroom body neurons to support olfactory intermediate-term memory in the adult ; Belongs to the MICU1 family. MICU1 subfamily. | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion. Belongs to the LETM1 family. | 0.934 |
MICU1 | MCU | FBpp0111941 | FBpp0300166 | Calcium uptake protein 1 homolog, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (Probable). During development, required in alpha/beta or gamma mushroom body neurons to support olfactory intermediate-term memory in the adult ; Belongs to the MICU1 family. MICU1 subfamily. | Calcium uniporter protein, mitochondrial; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore- forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Together with Itpr, has a role in oxidative stress-induced ER-mitochondria calcium transfer. During pupation, required for memory function in mushroom body neurons. Belongs to the MCU (TC 1.A.77) family. | 0.998 |
OXA1L | Letm1 | FBpp0076000 | FBpp0072255 | OXA1L mitochondrial inner membrane protein, isoform A; Membrane insertase activity. It is involved in the biological process described with: protein insertion into mitochondrial inner membrane from matrix; mitochondrial cytochrome c oxidase assembly; respiratory chain complex IV assembly; protein insertion into membrane. | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion. Belongs to the LETM1 family. | 0.764 |