node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG42660 | pain | FBpp0312123 | FBpp0072323 | MIP06256p. | Transient receptor potential cation channel protein painless; Receptor-activated non-selective cation channel involved in detection of pain sensation due to high temperature. Involved in heat nociception by being activated by noxious temperature of 38 degrees Celsius; Belongs to the transient receptor (TC 1.A.4) family. | 0.461 |
CaMKII | JhI-26 | FBpp0289608 | FBpp0086283 | Calcium/calmodulin-dependent protein kinase II (CaMKII) encodes an abundant Ca[2+]-calmodulin-regulated serine/threonine protein kinase. In neurons it has a wide range of substrates in multiple subcellular compartments, regulating synaptic plasticity, excitability and cytoskeletal interactions. | Juvenile hormone-inducible protein 26 (JhI-26) encodes a sperm protein. Overexpression of JhI-26 in males causes upregulation of the male accessory gland protein (Acp) gene CG10433, higher embryonic lethality and reduction of receptivity to remating in mated females. | 0.493 |
CaMKII | PMCA | FBpp0289608 | FBpp0293013 | Calcium/calmodulin-dependent protein kinase II (CaMKII) encodes an abundant Ca[2+]-calmodulin-regulated serine/threonine protein kinase. In neurons it has a wide range of substrates in multiple subcellular compartments, regulating synaptic plasticity, excitability and cytoskeletal interactions. | Plasma membrane calcium ATPase (PMCA) encodes a P-type ion pump found in the plasma membrane. It functions as a low-capacity, high-affinity Ca[2+]-extrusion mechanism, which is required for maintaining resting Ca[2+] levels in all cells. In the larval neuromuscular junction it plays an important role in restoring resting Ca[2+] levels after pre- or post-synaptic Ca[2+] influx. | 0.595 |
CaMKII | RpS27A | FBpp0289608 | FBpp0079606 | Calcium/calmodulin-dependent protein kinase II (CaMKII) encodes an abundant Ca[2+]-calmodulin-regulated serine/threonine protein kinase. In neurons it has a wide range of substrates in multiple subcellular compartments, regulating synaptic plasticity, excitability and cytoskeletal interactions. | Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involve [...] | 0.405 |
CaMKII | SPoCk | FBpp0289608 | FBpp0304415 | Calcium/calmodulin-dependent protein kinase II (CaMKII) encodes an abundant Ca[2+]-calmodulin-regulated serine/threonine protein kinase. In neurons it has a wide range of substrates in multiple subcellular compartments, regulating synaptic plasticity, excitability and cytoskeletal interactions. | Secretory Pathway Calcium atpase (SPoCk) encodes a transporting ATPase with roles in the maintenance of cellular Ca2+ homeostasis; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. | 0.526 |
CaMKII | pain | FBpp0289608 | FBpp0072323 | Calcium/calmodulin-dependent protein kinase II (CaMKII) encodes an abundant Ca[2+]-calmodulin-regulated serine/threonine protein kinase. In neurons it has a wide range of substrates in multiple subcellular compartments, regulating synaptic plasticity, excitability and cytoskeletal interactions. | Transient receptor potential cation channel protein painless; Receptor-activated non-selective cation channel involved in detection of pain sensation due to high temperature. Involved in heat nociception by being activated by noxious temperature of 38 degrees Celsius; Belongs to the transient receptor (TC 1.A.4) family. | 0.507 |
JhI-26 | CaMKII | FBpp0086283 | FBpp0289608 | Juvenile hormone-inducible protein 26 (JhI-26) encodes a sperm protein. Overexpression of JhI-26 in males causes upregulation of the male accessory gland protein (Acp) gene CG10433, higher embryonic lethality and reduction of receptivity to remating in mated females. | Calcium/calmodulin-dependent protein kinase II (CaMKII) encodes an abundant Ca[2+]-calmodulin-regulated serine/threonine protein kinase. In neurons it has a wide range of substrates in multiple subcellular compartments, regulating synaptic plasticity, excitability and cytoskeletal interactions. | 0.493 |
JhI-26 | PMCA | FBpp0086283 | FBpp0293013 | Juvenile hormone-inducible protein 26 (JhI-26) encodes a sperm protein. Overexpression of JhI-26 in males causes upregulation of the male accessory gland protein (Acp) gene CG10433, higher embryonic lethality and reduction of receptivity to remating in mated females. | Plasma membrane calcium ATPase (PMCA) encodes a P-type ion pump found in the plasma membrane. It functions as a low-capacity, high-affinity Ca[2+]-extrusion mechanism, which is required for maintaining resting Ca[2+] levels in all cells. In the larval neuromuscular junction it plays an important role in restoring resting Ca[2+] levels after pre- or post-synaptic Ca[2+] influx. | 0.479 |
JhI-26 | SPoCk | FBpp0086283 | FBpp0304415 | Juvenile hormone-inducible protein 26 (JhI-26) encodes a sperm protein. Overexpression of JhI-26 in males causes upregulation of the male accessory gland protein (Acp) gene CG10433, higher embryonic lethality and reduction of receptivity to remating in mated females. | Secretory Pathway Calcium atpase (SPoCk) encodes a transporting ATPase with roles in the maintenance of cellular Ca2+ homeostasis; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. | 0.539 |
JhI-26 | pain | FBpp0086283 | FBpp0072323 | Juvenile hormone-inducible protein 26 (JhI-26) encodes a sperm protein. Overexpression of JhI-26 in males causes upregulation of the male accessory gland protein (Acp) gene CG10433, higher embryonic lethality and reduction of receptivity to remating in mated females. | Transient receptor potential cation channel protein painless; Receptor-activated non-selective cation channel involved in detection of pain sensation due to high temperature. Involved in heat nociception by being activated by noxious temperature of 38 degrees Celsius; Belongs to the transient receptor (TC 1.A.4) family. | 0.502 |
Ork1 | pain | FBpp0310181 | FBpp0072323 | Open rectifier K[+] channel 1 (Ork1) encodes a member of the two pore open rectifier potassium channel gene family. It contributes to the regulation of membrane resting potential. The primary gating mechanism for the product of Ork1 appears to be based on phosphorylation of multiple serine, threonine and tyrosine residues in the large intracellular C-terminal tail. | Transient receptor potential cation channel protein painless; Receptor-activated non-selective cation channel involved in detection of pain sensation due to high temperature. Involved in heat nociception by being activated by noxious temperature of 38 degrees Celsius; Belongs to the transient receptor (TC 1.A.4) family. | 0.493 |
PMCA | CaMKII | FBpp0293013 | FBpp0289608 | Plasma membrane calcium ATPase (PMCA) encodes a P-type ion pump found in the plasma membrane. It functions as a low-capacity, high-affinity Ca[2+]-extrusion mechanism, which is required for maintaining resting Ca[2+] levels in all cells. In the larval neuromuscular junction it plays an important role in restoring resting Ca[2+] levels after pre- or post-synaptic Ca[2+] influx. | Calcium/calmodulin-dependent protein kinase II (CaMKII) encodes an abundant Ca[2+]-calmodulin-regulated serine/threonine protein kinase. In neurons it has a wide range of substrates in multiple subcellular compartments, regulating synaptic plasticity, excitability and cytoskeletal interactions. | 0.595 |
PMCA | JhI-26 | FBpp0293013 | FBpp0086283 | Plasma membrane calcium ATPase (PMCA) encodes a P-type ion pump found in the plasma membrane. It functions as a low-capacity, high-affinity Ca[2+]-extrusion mechanism, which is required for maintaining resting Ca[2+] levels in all cells. In the larval neuromuscular junction it plays an important role in restoring resting Ca[2+] levels after pre- or post-synaptic Ca[2+] influx. | Juvenile hormone-inducible protein 26 (JhI-26) encodes a sperm protein. Overexpression of JhI-26 in males causes upregulation of the male accessory gland protein (Acp) gene CG10433, higher embryonic lethality and reduction of receptivity to remating in mated females. | 0.479 |
PMCA | SPoCk | FBpp0293013 | FBpp0304415 | Plasma membrane calcium ATPase (PMCA) encodes a P-type ion pump found in the plasma membrane. It functions as a low-capacity, high-affinity Ca[2+]-extrusion mechanism, which is required for maintaining resting Ca[2+] levels in all cells. In the larval neuromuscular junction it plays an important role in restoring resting Ca[2+] levels after pre- or post-synaptic Ca[2+] influx. | Secretory Pathway Calcium atpase (SPoCk) encodes a transporting ATPase with roles in the maintenance of cellular Ca2+ homeostasis; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. | 0.931 |
PMCA | pain | FBpp0293013 | FBpp0072323 | Plasma membrane calcium ATPase (PMCA) encodes a P-type ion pump found in the plasma membrane. It functions as a low-capacity, high-affinity Ca[2+]-extrusion mechanism, which is required for maintaining resting Ca[2+] levels in all cells. In the larval neuromuscular junction it plays an important role in restoring resting Ca[2+] levels after pre- or post-synaptic Ca[2+] influx. | Transient receptor potential cation channel protein painless; Receptor-activated non-selective cation channel involved in detection of pain sensation due to high temperature. Involved in heat nociception by being activated by noxious temperature of 38 degrees Celsius; Belongs to the transient receptor (TC 1.A.4) family. | 0.623 |
RpS27A | CaMKII | FBpp0079606 | FBpp0289608 | Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involve [...] | Calcium/calmodulin-dependent protein kinase II (CaMKII) encodes an abundant Ca[2+]-calmodulin-regulated serine/threonine protein kinase. In neurons it has a wide range of substrates in multiple subcellular compartments, regulating synaptic plasticity, excitability and cytoskeletal interactions. | 0.405 |
RpS27A | SPoCk | FBpp0079606 | FBpp0304415 | Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involve [...] | Secretory Pathway Calcium atpase (SPoCk) encodes a transporting ATPase with roles in the maintenance of cellular Ca2+ homeostasis; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. | 0.456 |
RpS27A | pain | FBpp0079606 | FBpp0072323 | Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involve [...] | Transient receptor potential cation channel protein painless; Receptor-activated non-selective cation channel involved in detection of pain sensation due to high temperature. Involved in heat nociception by being activated by noxious temperature of 38 degrees Celsius; Belongs to the transient receptor (TC 1.A.4) family. | 0.479 |
SPoCk | CaMKII | FBpp0304415 | FBpp0289608 | Secretory Pathway Calcium atpase (SPoCk) encodes a transporting ATPase with roles in the maintenance of cellular Ca2+ homeostasis; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. | Calcium/calmodulin-dependent protein kinase II (CaMKII) encodes an abundant Ca[2+]-calmodulin-regulated serine/threonine protein kinase. In neurons it has a wide range of substrates in multiple subcellular compartments, regulating synaptic plasticity, excitability and cytoskeletal interactions. | 0.526 |
SPoCk | JhI-26 | FBpp0304415 | FBpp0086283 | Secretory Pathway Calcium atpase (SPoCk) encodes a transporting ATPase with roles in the maintenance of cellular Ca2+ homeostasis; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. | Juvenile hormone-inducible protein 26 (JhI-26) encodes a sperm protein. Overexpression of JhI-26 in males causes upregulation of the male accessory gland protein (Acp) gene CG10433, higher embryonic lethality and reduction of receptivity to remating in mated females. | 0.539 |