Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
mthl14Probable G-protein coupled receptor Mth-like 14; G protein-coupled receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway. (533 aa)    
Predicted Functional Partners:
mthl5
Methuselah-like 5 (mthl5) encodes a G protein-coupled receptor involved in heart morphogenesis.
      
 0.896
mthl1
Methuselah-like 1 (mthl1) encodes a G protein coupled receptor (GPCR) in the Methuselah clade of GPCRs. It interacts with the secreted morphogen encoded by fog to specify patterns of epithelial tissue folding during gastrulation and wing imaginal disc folding. Upon binding to the product of fog, the product of mthl1 activates apical constriction through the Concertina-RhoGEF2-Rho pathway.
      
 0.829
mthl12
Probable G-protein coupled receptor Mth-like 12; G protein-coupled receptor activity. It is involved in the biological process described with: determination of adult lifespan; cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; response to starvation.
      
 0.819
mthl9
Probable G-protein coupled receptor Mth-like 9; G protein-coupled receptor activity. It is involved in the biological process described with: response to starvation; G protein-coupled receptor signaling pathway; determination of adult lifespan.
   
  
 0.786
mthl7
Probable G-protein coupled receptor Mth-like 7; G protein-coupled receptor activity. It is involved in the biological process described with: determination of adult lifespan; cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; response to starvation; Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
      
 0.743
mthl13
Methuselah-like 13; G protein-coupled receptor activity. It is involved in the biological process described with: cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway.
      
 0.653
mthl6
Probable G-protein coupled receptor Mth-like 6; G protein-coupled receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway; response to starvation; cell surface receptor signaling pathway; determination of adult lifespan.
      
 0.646
mthl8
Probable G-protein coupled receptor Mth-like 8; G protein-coupled receptor activity. It is involved in the biological process described with: response to starvation; G protein-coupled receptor signaling pathway; determination of adult lifespan.
   
  
 0.539
Cirl
Latrophilin Cirl; Latrotoxin receptor activity; G protein-coupled receptor activity; carbohydrate binding; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
      
 0.476
mthl15
Methuselah-like 15, isoform C; G protein-coupled receptor activity. It is involved in the biological process described with: cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway.
      
0.425
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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