Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ttm2Mitochondrial import inner membrane translocase subunit TIM50-B; Tiny tim 2 (ttm2) encodes a mitochondrial inner membrane protein that is involved in mitochondrial protein translocation and maintenance of mitochondrial membrane potential; Belongs to the TIM50 family. (409 aa)    
Predicted Functional Partners:
CG7382
GM05057p; It is involved in the biological process described with: protein import into mitochondrial matrix.
    
 0.983
Tim23
Translocase of inner mitochondrial membrane 23; Protein transmembrane transporter activity. It is involved in the biological process described with: protein import into mitochondrial matrix.
   
 0.982
CG1409
Uncharacterized protein; It is involved in the biological process described with: protein import into mitochondrial matrix.
   
 0.972
blp
Mitochondrial import inner membrane translocase subunit Tim16; Black pearl (blp) encodes a conserved mitochondrial inner membrane protein. Its loss decreases cytochrome c oxidase activity and causes ROS production, leading to melanotic lesions ("black pearls") in blp-deficient flies; Belongs to the TIM16/PAM16 family.
    
 0.969
Tim17a1
Probable mitochondrial import inner membrane translocase subunit Tim17 3; Tim17a1 (Tim17a1) encodes a subunit of the TIM23 complex, which is a presequence translocase responsible for transporting proteins across the inner mitochondrial membrane. It modulates the gating of the transmembrane channel of TIM23 and plays a role in both matrix translocation as well as lateral membrane sorting.
   
 0.955
Tim17b2
Translocase inner membrane 17, isoform A; P-P-bond-hydrolysis-driven protein transmembrane transporter activity. It is involved in the biological process described with: protein import into mitochondrial matrix; protein targeting to mitochondrion.
   
 0.955
Tim17b1
Probable mitochondrial import inner membrane translocase subunit Tim17 1; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
   
 0.954
CG7394
Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).
   
 0.950
CG11779
Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family.
   
 0.949
CG1724
MIP34364p1; P-P-bond-hydrolysis-driven protein transmembrane transporter activity. It is involved in the biological process described with: protein import into mitochondrial matrix; protein targeting to mitochondrion.
   
 0.948
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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