STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP2Disco-interacting protein 2; May provide positional cues for axon pathfinding and patterning in the central nervous system (1773 aa)    
Predicted Functional Partners:
Dip2
Dorsal interacting protein 2; Protein binding; nucleic acid binding
      
 0.821
disco
Protein disconnected; Required for the establishment of stable connections between the larval optic nerves, the Bolwig's nerves, and their target cells in the brain during embryonic development
    
   0.791
gkt
Probable tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a sing [...]
      
 0.750
CG32944
Uncharacterized protein, isoform F; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: actin filament organization; protein phosphorylation; regulation of cell shape
      
 0.726
CG11505
La-related protein CG11505; Nucleotide binding; nucleic acid binding
      
 0.716
schlank
Schlank, isoform A; Schlank is a member of the Ceramide Synthases family involved in sphingolipid metabolism. It is essential for ceramide synthesis and modulates triacylglycerol levels and transcriptional expression of body fat metabolism regulators
      
 0.715
CG33521
annotation not available
   
  
 0.655
alpha-Cat
Catenin alpha; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties
   
  
 0.593
Eph
Protein tyrosine kinase activity; ephrin receptor activity; ATP binding; transmembrane receptor protein tyrosine kinase activity. It is involved in the biological process described with: axonogenesis; peripheral nervous system development; melanotic encapsulation of foreign target; protein phosphorylation; ephrin receptor signaling pathway; mushroom body development; signal transduction
   
    0.586
Zir
Zizimin-related; Rho guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: phagocytosis; melanotic encapsulation of foreign target; encapsulation of foreign target; regulation of Rho protein signal transduction; Belongs to the DOCK family
   
    0.582
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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