STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyxTransient receptor potential channel pyrexia; Receptor-activated non-selective cation channel involved in protection or tolerance from high temperature stress. Activated by temperatures above 40 degrees Celsius. More permeable to K(+) than to Na(+). May act in stress protection allow flies to survive in natural environments. (956 aa)    
Predicted Functional Partners:
iav
Inactive (iav) encodes a protein involved in the response to different stimuli such as startle, heat or sound; Belongs to the transient receptor (TC 1.A.4) family.
   
  
 0.717
nan
Nanchung, isoform B; Nanchung (nan) encodes a member of the transient Receptor Potential (TRP) channel family. It is involved in the response to different stimuli such as startle, humidity or sound.
      
 0.716
Trpgamma
Transient receptor potential-gamma protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction (By similarity). Forms a regulated cation channel when heteromultimerized with trpl; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily.
   
  
 0.709
nocte
No circadian temperature entrainment (nocte) encodes a protein involved in temperature compensation of the circadian clock.
      
 0.680
CG2678
Uncharacterized zinc finger protein CG2678; May be involved in transcriptional regulation.
    
 
 0.648
CG3457
LD17911p.
      
 0.629
brv1
Brivido-1; Calcium channel activity; calcium ion binding. It is involved in the biological process described with: detection of temperature stimulus involved in thermoception; detection of mechanical stimulus; cellular response to cold; calcium ion transport.
    
 
 0.611
Pkd2
Polycystic kidney disease 2 (Pkd2) encodes a calcium permeable cation channel of the transient receptor potential (TRP) family. Its roles include sperm motility, smooth muscle contraction, larval feeding behavior, detection of mechanical stimuli and cold nociception.
    
 
 0.551
Trpml
Transient receptor potential cation channel, mucolipin (Trpml) encodes a ion channel involved in autophagy, lateral inhibition and TOR signalling regulation.
      
 0.537
CG5846
LP07441p; It is involved in the biological process described with: regulation of transcription by RNA polymerase II.
  
     0.532
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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