Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
thoc7THO complex protein 7; The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress. Belongs to the THOC7 family. (288 aa)    
Predicted Functional Partners:
thoc5
THO complex subunit 5; The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress. Belongs to the THOC5 family.
   
 0.999
Hpr1
Hpr1 protein; It is involved in the biological process described with: mRNA export from nucleus in response to heat stress; mRNA export from nucleus; regulation of DNA-templated transcription, elongation; signal transduction.
   
 0.999
tex
Tex protein; It is involved in the biological process described with: mRNA export from nucleus.
   
 0.999
tho2
Tho2, isoform B; Tho2 (tho2) encodes a component of the THO complex that plays an essential role in nuclear export of mRNAs.
   
 0.999
thoc6
THO complex subunit 6; The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress. Belongs to the WD repeat THOC6 family.
   
 0.999
Hel25E
ATP-dependent RNA helicase WM6; Required for mRNA export out of the nucleus. Probable RNA helicase that may regulate entry into mitosis by down-regulating the expression of other genes whose activity may be rate-limiting for entry into mitosis during embryogenesis. Binds to salivary gland chromosomes and modifies position effect variegation. Promotes an open chromatin structure that favors transcription during development by regulating the spread of heterochromatin.
   
 0.997
Ref1
RNA and export factor binding protein 1; mRNA binding; nucleic acid binding. It is involved in the biological process described with: mRNA splicing, via spliceosome.
   
 0.994
CG8149
LD31448p; It is involved in the biological process described with: wing disc dorsal/ventral pattern formation; larval lymph gland hemopoiesis.
   
 0.980
CG9775
RE74585p.
    
 
 0.943
REPTOR-BP
REPTOR-binding partner; Transcriptional regulator that acts in the TORC1 signaling pathway to regulate energy homeostasis and promote survival during nutrient deprivation. Interacts with REPTOR to form a transcriptional activator complex that functions downstream of TORC1 to up-regulate the expression of most target genes induced by TORC1 inhibition. In the complex, acts to enhance the binding of the transcriptional activator REPTOR to the regulatory sequences of target genes. Under normal conditions TORC1 is active, inhibiting the formation of the REPTOR/REPTOR-BP complex by phosphory [...]
   
   0.913
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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