node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG43739 | CG46306 | FBpp0303290 | FBpp0402872 | annotation not available | Uncharacterized protein. | 0.892 |
CG43739 | mth | FBpp0303290 | FBpp0072470 | annotation not available | G-protein coupled receptor Mth; Involved in biological aging and stress response. Essential for adult survival. Required in the presynaptic motor neuron to up- regulate neurotransmitter exocytosis at larval glutamatergic neuromuscular junctions (NMJs). Regulates a step associated with docking and clustering of vesicles at release sites. SP/Acp70A and sun are agonists that activate mth in vitro. Belongs to the G-protein coupled receptor 2 family. Mth subfamily. | 0.491 |
CG46306 | CG43739 | FBpp0402872 | FBpp0303290 | Uncharacterized protein. | annotation not available | 0.892 |
CG46306 | mth | FBpp0402872 | FBpp0072470 | Uncharacterized protein. | G-protein coupled receptor Mth; Involved in biological aging and stress response. Essential for adult survival. Required in the presynaptic motor neuron to up- regulate neurotransmitter exocytosis at larval glutamatergic neuromuscular junctions (NMJs). Regulates a step associated with docking and clustering of vesicles at release sites. SP/Acp70A and sun are agonists that activate mth in vitro. Belongs to the G-protein coupled receptor 2 family. Mth subfamily. | 0.491 |
InR | Indy | FBpp0083519 | FBpp0074848 | Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. | Protein I'm not dead yet; Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage. Affinity for substrates is citrate > succinate > pyruvate. Fumarate, a- ketoglutarate, and glutarate are also transported, but not lactate. Transport mechanism that is not coupled to Na(+), K(+), [...] | 0.461 |
InR | mth | FBpp0083519 | FBpp0072470 | Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. | G-protein coupled receptor Mth; Involved in biological aging and stress response. Essential for adult survival. Required in the presynaptic motor neuron to up- regulate neurotransmitter exocytosis at larval glutamatergic neuromuscular junctions (NMJs). Regulates a step associated with docking and clustering of vesicles at release sites. SP/Acp70A and sun are agonists that activate mth in vitro. Belongs to the G-protein coupled receptor 2 family. Mth subfamily. | 0.523 |
Indy | InR | FBpp0074848 | FBpp0083519 | Protein I'm not dead yet; Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage. Affinity for substrates is citrate > succinate > pyruvate. Fumarate, a- ketoglutarate, and glutarate are also transported, but not lactate. Transport mechanism that is not coupled to Na(+), K(+), [...] | Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. | 0.461 |
Indy | Pcmt | FBpp0074848 | FBpp0078405 | Protein I'm not dead yet; Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage. Affinity for substrates is citrate > succinate > pyruvate. Fumarate, a- ketoglutarate, and glutarate are also transported, but not lactate. Transport mechanism that is not coupled to Na(+), K(+), [...] | Protein-L-isoaspartate(D-aspartate) O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl and D- aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. | 0.601 |
Indy | mth | FBpp0074848 | FBpp0072470 | Protein I'm not dead yet; Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage. Affinity for substrates is citrate > succinate > pyruvate. Fumarate, a- ketoglutarate, and glutarate are also transported, but not lactate. Transport mechanism that is not coupled to Na(+), K(+), [...] | G-protein coupled receptor Mth; Involved in biological aging and stress response. Essential for adult survival. Required in the presynaptic motor neuron to up- regulate neurotransmitter exocytosis at larval glutamatergic neuromuscular junctions (NMJs). Regulates a step associated with docking and clustering of vesicles at release sites. SP/Acp70A and sun are agonists that activate mth in vitro. Belongs to the G-protein coupled receptor 2 family. Mth subfamily. | 0.795 |
Pcmt | Indy | FBpp0078405 | FBpp0074848 | Protein-L-isoaspartate(D-aspartate) O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl and D- aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. | Protein I'm not dead yet; Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage. Affinity for substrates is citrate > succinate > pyruvate. Fumarate, a- ketoglutarate, and glutarate are also transported, but not lactate. Transport mechanism that is not coupled to Na(+), K(+), [...] | 0.601 |
Pcmt | mld | FBpp0078405 | FBpp0293452 | Protein-L-isoaspartate(D-aspartate) O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl and D- aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. | Molting defective (mld) encodes a nuclear zinc finger protein required for ecdysone biosynthesis. | 0.465 |
Pcmt | mth | FBpp0078405 | FBpp0072470 | Protein-L-isoaspartate(D-aspartate) O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl and D- aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. | G-protein coupled receptor Mth; Involved in biological aging and stress response. Essential for adult survival. Required in the presynaptic motor neuron to up- regulate neurotransmitter exocytosis at larval glutamatergic neuromuscular junctions (NMJs). Regulates a step associated with docking and clustering of vesicles at release sites. SP/Acp70A and sun are agonists that activate mth in vitro. Belongs to the G-protein coupled receptor 2 family. Mth subfamily. | 0.463 |
Pcmt | stc | FBpp0078405 | FBpp0080265 | Protein-L-isoaspartate(D-aspartate) O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl and D- aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. | Protein shuttle craft; Plays an essential role during the late stages of embryonic neurogenesis. May either fine-tune the guidance or the spatial maintenance of the migrating SNB and in nerve roots, which are composed of axons originating from distinct groups of motor neurons and may be required to either guide or maintain the position of these nerves along a direct and straight path to their ultimate targets in particular muscle fields. May play a role in egg chamber development and/or may confer essential maternal contributions to the early embryo. | 0.454 |
Rpn11 | mth | FBpp0078664 | FBpp0072470 | 26S proteasome non-ATPase regulatory subunit 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). Belongs to the peptidase M67A family. PSMD14 subfamily. | G-protein coupled receptor Mth; Involved in biological aging and stress response. Essential for adult survival. Required in the presynaptic motor neuron to up- regulate neurotransmitter exocytosis at larval glutamatergic neuromuscular junctions (NMJs). Regulates a step associated with docking and clustering of vesicles at release sites. SP/Acp70A and sun are agonists that activate mth in vitro. Belongs to the G-protein coupled receptor 2 family. Mth subfamily. | 0.493 |
mld | Pcmt | FBpp0293452 | FBpp0078405 | Molting defective (mld) encodes a nuclear zinc finger protein required for ecdysone biosynthesis. | Protein-L-isoaspartate(D-aspartate) O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl and D- aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. | 0.465 |
mld | ms(2)35Ci | FBpp0293452 | FBpp0304649 | Molting defective (mld) encodes a nuclear zinc finger protein required for ecdysone biosynthesis. | Male sterile (2) 35Ci, isoform A; It is involved in the biological process described with: spermatid differentiation. | 0.625 |
mld | mth | FBpp0293452 | FBpp0072470 | Molting defective (mld) encodes a nuclear zinc finger protein required for ecdysone biosynthesis. | G-protein coupled receptor Mth; Involved in biological aging and stress response. Essential for adult survival. Required in the presynaptic motor neuron to up- regulate neurotransmitter exocytosis at larval glutamatergic neuromuscular junctions (NMJs). Regulates a step associated with docking and clustering of vesicles at release sites. SP/Acp70A and sun are agonists that activate mth in vitro. Belongs to the G-protein coupled receptor 2 family. Mth subfamily. | 0.602 |
mld | stc | FBpp0293452 | FBpp0080265 | Molting defective (mld) encodes a nuclear zinc finger protein required for ecdysone biosynthesis. | Protein shuttle craft; Plays an essential role during the late stages of embryonic neurogenesis. May either fine-tune the guidance or the spatial maintenance of the migrating SNB and in nerve roots, which are composed of axons originating from distinct groups of motor neurons and may be required to either guide or maintain the position of these nerves along a direct and straight path to their ultimate targets in particular muscle fields. May play a role in egg chamber development and/or may confer essential maternal contributions to the early embryo. | 0.638 |
ms(2)35Ci | mld | FBpp0304649 | FBpp0293452 | Male sterile (2) 35Ci, isoform A; It is involved in the biological process described with: spermatid differentiation. | Molting defective (mld) encodes a nuclear zinc finger protein required for ecdysone biosynthesis. | 0.625 |
ms(2)35Ci | mth | FBpp0304649 | FBpp0072470 | Male sterile (2) 35Ci, isoform A; It is involved in the biological process described with: spermatid differentiation. | G-protein coupled receptor Mth; Involved in biological aging and stress response. Essential for adult survival. Required in the presynaptic motor neuron to up- regulate neurotransmitter exocytosis at larval glutamatergic neuromuscular junctions (NMJs). Regulates a step associated with docking and clustering of vesicles at release sites. SP/Acp70A and sun are agonists that activate mth in vitro. Belongs to the G-protein coupled receptor 2 family. Mth subfamily. | 0.493 |