STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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msd1Augmin complex subunit msd1; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. msd1 is required for microtubule nucleation from within the mitotic spindle and for localization of Grip71 to centrosomes and mitotic spindle. (138 aa)    
Predicted Functional Partners:
msd5
Augmin complex subunit msd5; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules.
   
 
 0.995
wac
Augmin complex subunit wac; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. wac is dispensable for somatic mitosis and for assembly of spindle microtubules in oocytes during female meiosis but is required during female meiosis for chromosome alignment and segregation. It is required for microtubule assembly near spindle poles in oocytes. It is also required for acentrosomal microtubule nucleation and [...]
   
 
 0.986
dgt2
Augmin complex subunit dgt2; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt2 binds to microtubules in vitro.
   
 
 0.986
dgt6
Augmin complex subunit dgt6; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt6 is required for kinetochore fiber formation, mediating nucleation and/or initial stabilization of chromosome-induced microtubules ; Belongs to the HAUS6 family.
   
 
 0.975
dgt4
Augmin complex subunit dgt4; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules.
   
 
 0.974
dgt5
Augmin complex subunit dgt5; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules.
   
 
 0.969
dgt3
Augmin complex subunit dgt3; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules ; Belongs to the HAUS3 family.
   
 
 0.968
mei-38
Meiotic 38 (mei-38) encodes a microtubule-associated protein that functions in mitosis and meiosis.
   
  
 0.837
mad2
RE72064p; Mad2 (mad2) encodes a conserved component of the spindle checkpoint. During mitosis, it is recruited to unattached kinetochores, where it binds the products of Mad1 and fzy, promoting the assembly of the mitotic checkpoint complex. During interphase, the product of mad2 is intranuclear, bound to the product of Mad1, and associated primarily with the nuclear pore complex.
   
    0.784
aurB
Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis.
   
    0.666
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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