STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
l(3)02640Lethal (3) 02640; Hydroxymethylbilane synthase activity. It is involved in the biological process described with: heme biosynthetic process; peptidyl-pyrromethane cofactor linkage. (652 aa)    
Predicted Functional Partners:
Pbgs
Delta-aminolevulinic acid dehydratase; Zinc ion binding; porphobilinogen synthase activity. It is involved in the biological process described with: heme biosynthetic process; Belongs to the ALAD family.
 
 0.998
Uros2
uroporphyrinogen-III synthase activity. It is involved in the biological process described with: heme biosynthetic process; uroporphyrinogen III biosynthetic process.
  
 0.993
Uros1
uroporphyrinogen-III synthase activity. It is involved in the biological process described with: heme biosynthetic process; uroporphyrinogen III biosynthetic process.
  
 0.993
Urod
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.976
FeCH
Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
  
  
 0.841
ATP8A
ATP binding; magnesium ion binding; ATPase-coupled intramembrane lipid transporter activity. It is involved in the biological process described with: phospholipid translocation; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
   
  
 0.790
Coprox
Oxygen-dependent coproporphyrinogen-III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX (By similarity).
  
  
 0.767
Ppox
Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
  
  
 0.760
GluProRS
Bifunctional glutamate/proline--tRNA ligase; Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.
  
  
 0.743
SdhA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Maintaining electron transport chain function is required to prevent neurodegenerative changes seen in both early- and late-onset disorders.
  
  
 0.727
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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