node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG12084 | CG34401 | FBpp0072595 | FBpp0423174 | Protein zer-1 homolog; Serves as substrate adapter subunit in an E3 ubiquitin ligase complex CG12084-cul-2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation. | Uncharacterized protein, isoform C; Zinc ion binding. It is involved in the biological process described with: regulation of axon guidance. | 0.547 |
CG12084 | Cul2 | FBpp0072595 | FBpp0085254 | Protein zer-1 homolog; Serves as substrate adapter subunit in an E3 ubiquitin ligase complex CG12084-cul-2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation. | Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family. | 0.930 |
CG12084 | EloB | FBpp0072595 | FBpp0083354 | Protein zer-1 homolog; Serves as substrate adapter subunit in an E3 ubiquitin ligase complex CG12084-cul-2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation. | Elongin B (EloB) encodes an essential protein for development that participates in the control of wing cell identity. EloB, EloC and EloA encode for subunits of the Elongin complex, which interacts in vivo with the chromatin factor encoded by corto. | 0.711 |
CG12084 | EloC | FBpp0072595 | FBpp0085725 | Protein zer-1 homolog; Serves as substrate adapter subunit in an E3 ubiquitin ligase complex CG12084-cul-2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation. | Elongin C (EloC) encodes an essential protein for development that participates in the control of wing cell identity. EloB, EloC and EloA encode for subunits of the Elongin complex, which interacts in vivo with the chromatin factor encoded by corto. | 0.845 |
CG12084 | Lrr47 | FBpp0072595 | FBpp0304061 | Protein zer-1 homolog; Serves as substrate adapter subunit in an E3 ubiquitin ligase complex CG12084-cul-2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation. | Leucine-rich repeat 47, isoform A; It is involved in the biological process described with: Ras protein signal transduction; signal transduction. | 0.584 |
CG12084 | Pat1 | FBpp0072595 | FBpp0070906 | Protein zer-1 homolog; Serves as substrate adapter subunit in an E3 ubiquitin ligase complex CG12084-cul-2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation. | Protein interacting with APP tail-1 (Pat1) encodes a protein required for the product of Khc to transport cargo and to maximize its motility. In oocytes the products of Pat1 and Klc act in a redundant manner. | 0.559 |
CG12084 | Roc1a | FBpp0072595 | FBpp0300874 | Protein zer-1 homolog; Serves as substrate adapter subunit in an E3 ubiquitin ligase complex CG12084-cul-2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation. | RING-box protein 1A; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Required for the specific SCF-dependent proteolysis of CI, but not that of ARM, suggesting that it also participates in the selection of substrates inside the SCF complex. During early metamorphosis, part of [...] | 0.639 |
CG12084 | Vps11 | FBpp0072595 | FBpp0070045 | Protein zer-1 homolog; Serves as substrate adapter subunit in an E3 ubiquitin ligase complex CG12084-cul-2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation. | Vacuolar protein sorting 11 (Vps11) encodes a Class C Vps core subunit of HOPS, a heterohexameric tethering complex that consists of the products of car, dor, lt, Vps11, Vps16A and Vps39. HOPS tethers autophagosomes or late endosomes with lysosomes to facilitate fusion. The product of Vps11 roles include autophagosome-lysosome fusion, late endosome-lysosome fusion and biosynthetic trafficking to lysosomes. | 0.432 |
CG12084 | elB | FBpp0072595 | FBpp0309706 | Protein zer-1 homolog; Serves as substrate adapter subunit in an E3 ubiquitin ligase complex CG12084-cul-2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation. | Zinc finger protein Elbow; May negatively regulate Notch-induced cell proliferation in the eye-head primordium. May act in leg and wing primordia to negatively regulate body-wall specifying genes and thereby promote appendage formation. Required for tracheal development. Belongs to the Elbow/Noc family. | 0.544 |
CG12084 | slim | FBpp0072595 | FBpp0085872 | Protein zer-1 homolog; Serves as substrate adapter subunit in an E3 ubiquitin ligase complex CG12084-cul-2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation. | Kelch domain-containing protein 10 homolog; Activates the Pk92B/DASK1-MAPK signaling cascade. | 0.561 |
CG34401 | CG12084 | FBpp0423174 | FBpp0072595 | Uncharacterized protein, isoform C; Zinc ion binding. It is involved in the biological process described with: regulation of axon guidance. | Protein zer-1 homolog; Serves as substrate adapter subunit in an E3 ubiquitin ligase complex CG12084-cul-2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation. | 0.547 |
CG34401 | Cul2 | FBpp0423174 | FBpp0085254 | Uncharacterized protein, isoform C; Zinc ion binding. It is involved in the biological process described with: regulation of axon guidance. | Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family. | 0.668 |
CG34401 | EloB | FBpp0423174 | FBpp0083354 | Uncharacterized protein, isoform C; Zinc ion binding. It is involved in the biological process described with: regulation of axon guidance. | Elongin B (EloB) encodes an essential protein for development that participates in the control of wing cell identity. EloB, EloC and EloA encode for subunits of the Elongin complex, which interacts in vivo with the chromatin factor encoded by corto. | 0.683 |
CG34401 | EloC | FBpp0423174 | FBpp0085725 | Uncharacterized protein, isoform C; Zinc ion binding. It is involved in the biological process described with: regulation of axon guidance. | Elongin C (EloC) encodes an essential protein for development that participates in the control of wing cell identity. EloB, EloC and EloA encode for subunits of the Elongin complex, which interacts in vivo with the chromatin factor encoded by corto. | 0.651 |
CG34401 | Pat1 | FBpp0423174 | FBpp0070906 | Uncharacterized protein, isoform C; Zinc ion binding. It is involved in the biological process described with: regulation of axon guidance. | Protein interacting with APP tail-1 (Pat1) encodes a protein required for the product of Khc to transport cargo and to maximize its motility. In oocytes the products of Pat1 and Klc act in a redundant manner. | 0.550 |
CG34401 | Roc1a | FBpp0423174 | FBpp0300874 | Uncharacterized protein, isoform C; Zinc ion binding. It is involved in the biological process described with: regulation of axon guidance. | RING-box protein 1A; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Required for the specific SCF-dependent proteolysis of CI, but not that of ARM, suggesting that it also participates in the selection of substrates inside the SCF complex. During early metamorphosis, part of [...] | 0.556 |
CG34401 | slim | FBpp0423174 | FBpp0085872 | Uncharacterized protein, isoform C; Zinc ion binding. It is involved in the biological process described with: regulation of axon guidance. | Kelch domain-containing protein 10 homolog; Activates the Pk92B/DASK1-MAPK signaling cascade. | 0.540 |
Cul2 | CG12084 | FBpp0085254 | FBpp0072595 | Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family. | Protein zer-1 homolog; Serves as substrate adapter subunit in an E3 ubiquitin ligase complex CG12084-cul-2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation. | 0.930 |
Cul2 | CG34401 | FBpp0085254 | FBpp0423174 | Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family. | Uncharacterized protein, isoform C; Zinc ion binding. It is involved in the biological process described with: regulation of axon guidance. | 0.668 |
Cul2 | EloB | FBpp0085254 | FBpp0083354 | Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family. | Elongin B (EloB) encodes an essential protein for development that participates in the control of wing cell identity. EloB, EloC and EloA encode for subunits of the Elongin complex, which interacts in vivo with the chromatin factor encoded by corto. | 0.999 |