Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Abl | Ptp61F | FBpp0303166 | FBpp0072602 | Tyrosine-protein kinase Abl; Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways. | Tyrosine-protein phosphatase non-receptor type 61F; Non-receptor protein tyrosine phosphatase required for maintaining Dock in its non-phosphorylated state. | 0.715 |
| Abl | dock | FBpp0303166 | FBpp0077679 | Tyrosine-protein kinase Abl; Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways. | Dreadlocks, isoform B; It is involved in the biological process described with: axon guidance; myoblast fusion; negative regulation of insulin receptor signaling pathway. | 0.608 |
| Abl | pr | FBpp0303166 | FBpp0088417 | Tyrosine-protein kinase Abl; Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways. | 6-pyruvoyl tetrahydrobiopterin synthase; Required for pigment and biopterin synthesis. Belongs to the PTPS family. | 0.417 |
| InR | Ptp61F | FBpp0083519 | FBpp0072602 | Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. | Tyrosine-protein phosphatase non-receptor type 61F; Non-receptor protein tyrosine phosphatase required for maintaining Dock in its non-phosphorylated state. | 0.966 |
| InR | Stat92E | FBpp0083519 | FBpp0306651 | Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. | Signal-transducer and activator of transcription protein at 92E (Stat92E) encodes a transcription factor that shuttles between the cytosol and nucleus and functions in the JAK/STAT pathway. Its roles include proliferation, growth control, organismal metabolism, cell competition, stem cell self-renewal, immunity and developmental patterning. | 0.507 |
| InR | dock | FBpp0083519 | FBpp0077679 | Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. | Dreadlocks, isoform B; It is involved in the biological process described with: axon guidance; myoblast fusion; negative regulation of insulin receptor signaling pathway. | 0.695 |
| InR | dome | FBpp0083519 | FBpp0074525 | Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. | Cytokine receptor; Critical for epithelial morphogenesis during oogenesis; border cell migration. Required in the germarium for the polarization of follicle cells during encapsulation of germline cells. Required for embryonic segmentation and trachea specification. Essential receptor molecule for upd and JAK/STAT signaling during oogenesis. | 0.423 |
| InR | upd2 | FBpp0083519 | FBpp0423083 | Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. | Unpaired 2 (upd2) encodes a secreted molecule that acts at a distance as a ligand for the JAK/STAT signal transduction pathway. upd2 mutants are viable due to redundancy with other Upd-family genes. | 0.679 |
| InR | upd3 | FBpp0083519 | FBpp0112376 | Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. | Unpaired 3 (upd3) encodes a "cytokine" (secreted protein) of the Unpaired family that can bind and activate the JAK-STAT receptor encoded by dome. It is induced in hemocytes or in the intestine upon damage to regulate the repair response in these tissues through JAK-STAT activation. | 0.471 |
| Ptp61F | Abl | FBpp0072602 | FBpp0303166 | Tyrosine-protein phosphatase non-receptor type 61F; Non-receptor protein tyrosine phosphatase required for maintaining Dock in its non-phosphorylated state. | Tyrosine-protein kinase Abl; Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways. | 0.715 |
| Ptp61F | InR | FBpp0072602 | FBpp0083519 | Tyrosine-protein phosphatase non-receptor type 61F; Non-receptor protein tyrosine phosphatase required for maintaining Dock in its non-phosphorylated state. | Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. | 0.966 |
| Ptp61F | Socs36E | FBpp0072602 | FBpp0302960 | Tyrosine-protein phosphatase non-receptor type 61F; Non-receptor protein tyrosine phosphatase required for maintaining Dock in its non-phosphorylated state. | Suppressor of cytokine signaling at 36E (Socs36E) encodes a negative regulator of the JAK/STAT and EGFR pathways. It is a transcriptional target of the product of Stat92E that mediates lysosomal degradation following pathway stimulation and inhibits basal pathway activity. | 0.802 |
| Ptp61F | Stat92E | FBpp0072602 | FBpp0306651 | Tyrosine-protein phosphatase non-receptor type 61F; Non-receptor protein tyrosine phosphatase required for maintaining Dock in its non-phosphorylated state. | Signal-transducer and activator of transcription protein at 92E (Stat92E) encodes a transcription factor that shuttles between the cytosol and nucleus and functions in the JAK/STAT pathway. Its roles include proliferation, growth control, organismal metabolism, cell competition, stem cell self-renewal, immunity and developmental patterning. | 0.950 |
| Ptp61F | dock | FBpp0072602 | FBpp0077679 | Tyrosine-protein phosphatase non-receptor type 61F; Non-receptor protein tyrosine phosphatase required for maintaining Dock in its non-phosphorylated state. | Dreadlocks, isoform B; It is involved in the biological process described with: axon guidance; myoblast fusion; negative regulation of insulin receptor signaling pathway. | 0.847 |
| Ptp61F | dome | FBpp0072602 | FBpp0074525 | Tyrosine-protein phosphatase non-receptor type 61F; Non-receptor protein tyrosine phosphatase required for maintaining Dock in its non-phosphorylated state. | Cytokine receptor; Critical for epithelial morphogenesis during oogenesis; border cell migration. Required in the germarium for the polarization of follicle cells during encapsulation of germline cells. Required for embryonic segmentation and trachea specification. Essential receptor molecule for upd and JAK/STAT signaling during oogenesis. | 0.745 |
| Ptp61F | hop | FBpp0072602 | FBpp0073313 | Tyrosine-protein phosphatase non-receptor type 61F; Non-receptor protein tyrosine phosphatase required for maintaining Dock in its non-phosphorylated state. | Tyrosine-protein kinase hopscotch; Tyrosine kinase of the non-receptor type, phosphorylates the marelle protein. Required maternally for the establishment of the normal array of embryonic segments: involved in the control of pair- rule gene transcription in a stripe-specific manner. Together with Hsp83 and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation. | 0.848 |
| Ptp61F | pr | FBpp0072602 | FBpp0088417 | Tyrosine-protein phosphatase non-receptor type 61F; Non-receptor protein tyrosine phosphatase required for maintaining Dock in its non-phosphorylated state. | 6-pyruvoyl tetrahydrobiopterin synthase; Required for pigment and biopterin synthesis. Belongs to the PTPS family. | 0.756 |
| Ptp61F | upd2 | FBpp0072602 | FBpp0423083 | Tyrosine-protein phosphatase non-receptor type 61F; Non-receptor protein tyrosine phosphatase required for maintaining Dock in its non-phosphorylated state. | Unpaired 2 (upd2) encodes a secreted molecule that acts at a distance as a ligand for the JAK/STAT signal transduction pathway. upd2 mutants are viable due to redundancy with other Upd-family genes. | 0.671 |
| Ptp61F | upd3 | FBpp0072602 | FBpp0112376 | Tyrosine-protein phosphatase non-receptor type 61F; Non-receptor protein tyrosine phosphatase required for maintaining Dock in its non-phosphorylated state. | Unpaired 3 (upd3) encodes a "cytokine" (secreted protein) of the Unpaired family that can bind and activate the JAK-STAT receptor encoded by dome. It is induced in hemocytes or in the intestine upon damage to regulate the repair response in these tissues through JAK-STAT activation. | 0.671 |
| Socs36E | Ptp61F | FBpp0302960 | FBpp0072602 | Suppressor of cytokine signaling at 36E (Socs36E) encodes a negative regulator of the JAK/STAT and EGFR pathways. It is a transcriptional target of the product of Stat92E that mediates lysosomal degradation following pathway stimulation and inhibits basal pathway activity. | Tyrosine-protein phosphatase non-receptor type 61F; Non-receptor protein tyrosine phosphatase required for maintaining Dock in its non-phosphorylated state. | 0.802 |
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