Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
CG33230MIP03820p; Protein-lysine N-methyltransferase activity. It is involved in the biological process described with: peptidyl-lysine monomethylation. (446 aa)    
Predicted Functional Partners:
ABCB7
ATP binding cassette subfamily B member 7 (ABCB7) encodes a transporter that likely dimerizes to form a functional transporter. It may act in the mitochondria to transport substrates necessary for the maturation of ICS proteins, which are involved in iron homeostasis.
 
      0.897
CG34117
GEO13368p1.
      
 0.863
CG33932
GEO12594p1; It is involved in the biological process described with: cellular calcium ion homeostasis.
      
 0.828
CG12170
3-oxoacyl-[acyl-carrier-protein] synthase activity. It is involved in the biological process described with: fatty acid biosynthetic process; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
      
 0.823
CG14270
RE03721p; It is involved in the biological process described with: protein insertion into mitochondrial inner membrane.
      
 0.821
Rpp20
Ribonuclease P protein subunit p20; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences (By similarity).
      
 0.821
mRpL42
Mitochondrial ribosomal protein L42, isoform A; Structural constituent of ribosome. It is involved in the biological process described with: mitochondrial translation; translation.
      
 0.816
MFS16
Major facilitator superfamily transporter 16, isoform B; Transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport.
      
 0.805
CG32281
tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
   
  
 0.794
SiaT
Beta-galactoside alpha-2,6-sialyltransferase; Sialyltransferase (SiaT) encodes an enzyme that functions in the sialylation pathway. It is required to produce sialylated glycans, which are important for nervous system function. It contributes to lifespan, locomotor abnormalities, response to heat and neuromuscular junction development; Belongs to the glycosyltransferase 29 family.
      
 0.761
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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