STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
oxtXylosyltransferase oxt; Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes; Belongs to the glycosyltransferase 14 family. XylT subfamily. (876 aa)    
Predicted Functional Partners:
beta4GalT7
Beta-4-galactosyltransferase 7 (beta4GalT7) encodes an enzyme that transfers a Gal to the Xyl-O-Ser in the tetrasaccharide structure of the protein-linkage region of glycosaminoglycans (GAGs). It is involved in Hh and Dpp signaling pathways mediated by GAGs in development.
     
 0.941
beta3GalTII
Hexosyltransferase; beta-1,3-Galactosyltransferase II (beta3GalTII) encodes a protein involved in the synthesis of a common linkage tetrasaccharide structure of heparan (HS) and chondroitin sulfates (CS). Its roles include regulation of several signaling pathways (Hh, Dpp, Wingless) mediated by HS and CS in development.
    
 
 0.920
Fancm
Fanconi anemia group M helicase (Fancm) encodes a protein that promotes repair of DNA interstrand crosslinks through the Fanconi anemia pathway and non-crossover repair of DNA double-strand breaks.
    
 
 0.849
dUTPase
Deoxyuridine triphosphatase, isoform A; dUTP diphosphatase activity; magnesium ion binding. It is involved in the biological process described with: dUMP biosynthetic process; dUTP metabolic process; dUTP catabolic process.
   
 
 0.816
mei-9
DNA repair endonuclease XPF; Implicated in recombination events during meiosis, mostly in meiotic exchange. May directly resolve Holliday junctions within recombination intermediates leading to DNA exchange. Also required for the repair of mismatches within meiotic heteroduplex DNA and for nucleotide excision repair.
   
 
 0.781
GalT1
Hexosyltransferase; Beta1,3-galactosyltransferase 1 (GalT1) encodes an enzyme involved in protein N-linked glycosylation.
   
  
 0.710
mus81
EG:BACR7A4.16 protein; Mus81 (mus81) encodes the catalytic subunit of the Mus81-mms4 structure-selective endonuclease that functions in DNA repair.
   
 
 0.700
Fur2
Furin-like protease 2; Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.
   
  
 0.693
CG45062
Uncharacterized protein, isoform A; ATPase activity; nucleotide binding; calcium transmembrane transporter activity, phosphorylative mechanism; proton-exporting ATPase activity, phosphorylative mechanism. It is involved in the biological process described with: calcium ion transmembrane transport; cellular calcium ion homeostasis.
    
 
 0.693
Fur1
Furin-like protease 1, isoforms 1/1-X/2; Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.
   
  
 0.684
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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