STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Acp62FAccessory gland protein Acp62F; Responsible for physiological and behavioral changes in mated female flies. May contribute to the toxicity of seminal fluid and the decreased life-span of mated females. May also affect neuromuscular events after mating concerning sperm storage and egg release. (115 aa)    
Predicted Functional Partners:
Acp29AB
Accessory gland protein 29AB (Acp29AB) encodes a predicted C-type lectin that is produced by the male accessory glands and transferred to females during mating. After transfer to mated females, the Acp29AB product is detected in sperm storage organs and in the hemolymph. It plays a role in retention of sperm in storage and sperm competition.
   
  
 0.985
Acp36DE
Accessory gland protein Acp36DE; Responsible for physiological and behavioral changes in mated female flies. Associates with sperm and localizes to specific regions of the female reproductive tract, including the sperm storage organs. It accelerates sperm accumulation into storage but does not mediate the entry of the first sperm into storage. Once sperm storage has initiated it seems to act as a guidance factor helping subsequent sperm move into storage, a corral concentrating sperm around the SSO entrances and/or a trigger for responses within the female that accelerate storage of sperm.
   
  
 0.985
SP
Accessory gland-specific peptide 70A; Male seminal protein which triggers short- and long-term post-mating behavioral responses (PMR) in female Drosophila. Binds initially to sperm where it is later cleaved to release an active peptide within the female reproductive tract. Signals via the sex peptide receptor (SPR) in female flies; may also act via other receptors. Moderates the activity of distinct neuronal circuitries in the female genital tract to promote specific PMRs including: enhanced ovulation, increased egg laying rate, increased feeding/foraging rate, induced antimicrobial pe [...]
   
  
 0.984
Acp26Aa
Accessory gland protein 26Aa (Acp26Aa) encodes a protein synthesized in male accessory glands. It is transferred during mating to females where it induces an increase in ovulation by relaxing the oviduct via activation of octopaminergic signaling.
   
  
 0.982
Acp76A
Accessory gland protein 76A (Acp76A) encodes a protein that shows homology to the serpin serine endopeptidase inhibitor family but is predicted to be non-inhibitory. It is produced in the male accessory glands and transferred to females during mating.
   
  
 0.972
Acp53Ea
Accessory gland protein Acp53Ea; Responsible for physiological and behavioral changes in mated female flies.
   
  
 0.964
CG6168
Uncharacterized protein, isoform B; CG6168 encodes a predicted metalloendopeptidase that is produced by the male accessory glands. CG6168 ectopic expression in females provides anti-microbial protection.
   
  
 0.957
Spn28F
Serpin 28F (Spn28F) encodes a predicted serine protease inhibitor. It is expressed in the male accessory glands and transferred to females during mating.
   
  
 0.945
Acp63F
Accessory gland protein 63F (Acp63F) encodes a protein produced by the male accessory glands and transferred to females during mating.
   
  
 0.944
Acp26Ab
Accessory gland protein 26Ab (Acp26Ab) encodes a peptide that is produced by male accessory glands and transferred to females during mating.
   
  
 0.943
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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