node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDase | CG9804 | FBpp0085011 | FBpp0078583 | Neutral ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition. Belongs to the neutral ceramidase family. | Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity). | 0.400 |
CDase | scramb2 | FBpp0085011 | FBpp0072875 | Neutral ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition. Belongs to the neutral ceramidase family. | Scramblase 2 (scramb2) encodes a protein that, together with the product of scramb1, has a modulatory function in the process of neurotransmission. They have a significant role in scrambling of phospholipids across the plasma membrane during apoptosis. | 0.401 |
CG33331 | scramb2 | FBpp0082457 | FBpp0072875 | Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. | Scramblase 2 (scramb2) encodes a protein that, together with the product of scramb1, has a modulatory function in the process of neurotransmission. They have a significant role in scrambling of phospholipids across the plasma membrane during apoptosis. | 0.606 |
CG7601 | scramb2 | FBpp0084910 | FBpp0072875 | Dehydrogenase/reductase SDR family protein 7-like; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Scramblase 2 (scramb2) encodes a protein that, together with the product of scramb1, has a modulatory function in the process of neurotransmission. They have a significant role in scrambling of phospholipids across the plasma membrane during apoptosis. | 0.420 |
CG9804 | CDase | FBpp0078583 | FBpp0085011 | Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity). | Neutral ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition. Belongs to the neutral ceramidase family. | 0.400 |
CG9804 | Ipp | FBpp0078583 | FBpp0082328 | Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity). | Inositol polyphosphate 1-phosphatase (Ipp) encodes a protein involved in synaptic transmission and inositol metabolism regulation. | 0.499 |
CG9804 | scramb2 | FBpp0078583 | FBpp0072875 | Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity). | Scramblase 2 (scramb2) encodes a protein that, together with the product of scramb1, has a modulatory function in the process of neurotransmission. They have a significant role in scrambling of phospholipids across the plasma membrane during apoptosis. | 0.839 |
Ipp | CG9804 | FBpp0082328 | FBpp0078583 | Inositol polyphosphate 1-phosphatase (Ipp) encodes a protein involved in synaptic transmission and inositol metabolism regulation. | Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity). | 0.499 |
Ipp | scramb2 | FBpp0082328 | FBpp0072875 | Inositol polyphosphate 1-phosphatase (Ipp) encodes a protein involved in synaptic transmission and inositol metabolism regulation. | Scramblase 2 (scramb2) encodes a protein that, together with the product of scramb1, has a modulatory function in the process of neurotransmission. They have a significant role in scrambling of phospholipids across the plasma membrane during apoptosis. | 0.495 |
ced-6 | scramb2 | FBpp0297720 | FBpp0072875 | PTB domain-containing adapter protein ced-6; Plays a role in axon pruning in larval mushroom body neurons during metamorphosis. Plays a role in the infiltration of glial cell processes into mushroom body lobes and the subsequent engulfment of degenerating axon branches. Involved in Drpr-mediated phagocytosis of apoptotic cells. Required for bacterial phagocytosis. During neuromuscular junction development, required for the clearance of pruned ghost boutons and presynaptic debris and for normal synaptic growth. | Scramblase 2 (scramb2) encodes a protein that, together with the product of scramb1, has a modulatory function in the process of neurotransmission. They have a significant role in scrambling of phospholipids across the plasma membrane during apoptosis. | 0.465 |
kat80 | scramb2 | FBpp0074026 | FBpp0072875 | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. | Scramblase 2 (scramb2) encodes a protein that, together with the product of scramb1, has a modulatory function in the process of neurotransmission. They have a significant role in scrambling of phospholipids across the plasma membrane during apoptosis. | 0.459 |
scramb2 | CDase | FBpp0072875 | FBpp0085011 | Scramblase 2 (scramb2) encodes a protein that, together with the product of scramb1, has a modulatory function in the process of neurotransmission. They have a significant role in scrambling of phospholipids across the plasma membrane during apoptosis. | Neutral ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition. Belongs to the neutral ceramidase family. | 0.401 |
scramb2 | CG33331 | FBpp0072875 | FBpp0082457 | Scramblase 2 (scramb2) encodes a protein that, together with the product of scramb1, has a modulatory function in the process of neurotransmission. They have a significant role in scrambling of phospholipids across the plasma membrane during apoptosis. | Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. | 0.606 |
scramb2 | CG7601 | FBpp0072875 | FBpp0084910 | Scramblase 2 (scramb2) encodes a protein that, together with the product of scramb1, has a modulatory function in the process of neurotransmission. They have a significant role in scrambling of phospholipids across the plasma membrane during apoptosis. | Dehydrogenase/reductase SDR family protein 7-like; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.420 |
scramb2 | CG9804 | FBpp0072875 | FBpp0078583 | Scramblase 2 (scramb2) encodes a protein that, together with the product of scramb1, has a modulatory function in the process of neurotransmission. They have a significant role in scrambling of phospholipids across the plasma membrane during apoptosis. | Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity). | 0.839 |
scramb2 | Ipp | FBpp0072875 | FBpp0082328 | Scramblase 2 (scramb2) encodes a protein that, together with the product of scramb1, has a modulatory function in the process of neurotransmission. They have a significant role in scrambling of phospholipids across the plasma membrane during apoptosis. | Inositol polyphosphate 1-phosphatase (Ipp) encodes a protein involved in synaptic transmission and inositol metabolism regulation. | 0.495 |
scramb2 | ced-6 | FBpp0072875 | FBpp0297720 | Scramblase 2 (scramb2) encodes a protein that, together with the product of scramb1, has a modulatory function in the process of neurotransmission. They have a significant role in scrambling of phospholipids across the plasma membrane during apoptosis. | PTB domain-containing adapter protein ced-6; Plays a role in axon pruning in larval mushroom body neurons during metamorphosis. Plays a role in the infiltration of glial cell processes into mushroom body lobes and the subsequent engulfment of degenerating axon branches. Involved in Drpr-mediated phagocytosis of apoptotic cells. Required for bacterial phagocytosis. During neuromuscular junction development, required for the clearance of pruned ghost boutons and presynaptic debris and for normal synaptic growth. | 0.465 |
scramb2 | kat80 | FBpp0072875 | FBpp0074026 | Scramblase 2 (scramb2) encodes a protein that, together with the product of scramb1, has a modulatory function in the process of neurotransmission. They have a significant role in scrambling of phospholipids across the plasma membrane during apoptosis. | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. | 0.459 |
scramb2 | subdued | FBpp0072875 | FBpp0291654 | Scramblase 2 (scramb2) encodes a protein that, together with the product of scramb1, has a modulatory function in the process of neurotransmission. They have a significant role in scrambling of phospholipids across the plasma membrane during apoptosis. | Anoctamin; Subdued (subdued) encodes a chloride ion channel activated by calcium and heat belonging to the TMEM16 family. Its roles include host defense against ingested pathogenic bacteria and modulation of sensory neuronal signaling. | 0.537 |
subdued | scramb2 | FBpp0291654 | FBpp0072875 | Anoctamin; Subdued (subdued) encodes a chloride ion channel activated by calcium and heat belonging to the TMEM16 family. Its roles include host defense against ingested pathogenic bacteria and modulation of sensory neuronal signaling. | Scramblase 2 (scramb2) encodes a protein that, together with the product of scramb1, has a modulatory function in the process of neurotransmission. They have a significant role in scrambling of phospholipids across the plasma membrane during apoptosis. | 0.537 |