STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG32281tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family. (457 aa)    
Predicted Functional Partners:
CG31381
LD10347p; tRNA dimethylallyltransferase activity; nucleic acid binding. It is involved in the biological process described with: tRNA modification; Belongs to the IPP transferase family.
   
  
 0.935
Tcs3
Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
   
  
 0.893
CG12975
Multifunctional methyltransferase subunit TRM112-like protein; Acts as an activator of both RNA and protein methyltransferases.
   
 
 0.842
CG33230
MIP03820p; Protein-lysine N-methyltransferase activity. It is involved in the biological process described with: peptidyl-lysine monomethylation.
   
  
 0.837
CG34117
GEO13368p1.
      
 0.836
CG33932
GEO12594p1; It is involved in the biological process described with: cellular calcium ion homeostasis.
   
  
 0.836
Rpp20
Ribonuclease P protein subunit p20; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences (By similarity).
   
  
 0.835
CG12170
3-oxoacyl-[acyl-carrier-protein] synthase activity. It is involved in the biological process described with: fatty acid biosynthetic process; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
      
 0.800
CG14270
RE03721p; It is involved in the biological process described with: protein insertion into mitochondrial inner membrane.
      
 0.795
mRpL42
Mitochondrial ribosomal protein L42, isoform A; Structural constituent of ribosome. It is involved in the biological process described with: mitochondrial translation; translation.
      
 0.791
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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