STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG14965LD47616p; Nucleic acid binding. (557 aa)    
Predicted Functional Partners:
CG14966
RE68649p.
   
  
 0.838
Atf-2
Activating transcription factor-2 (Atf-2) encodes a trancription factor required for heterochromatin assembly. It is involved in stress response and fat metabolism regulation.
      
 0.567
14-3-3zeta
14-3-3 protein zeta; Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. Acts upstream of Raf and downstream of Ras, and is essential for viability. Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob. Inhibits yki activity by restricting its nuclear localization. Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes.
    
 
 0.547
P58IPK
LD25575p; Misfolded protein binding; chaperone binding. It is involved in the biological process described with: protein folding in endoplasmic reticulum.
    
 
 0.541
DNAlig1
DNA ligase 1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
   
  
 0.536
CG10431
Uncharacterized protein, isoform A; Zinc ion binding; transcription regulatory region sequence-specific DNA binding. It is involved in the biological process described with: dendrite morphogenesis; regulation of transcription, DNA-templated.
   
  
 0.535
CG15436
LD32747p; Zinc ion binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific.
   
   0.518
CG12713
LD07058p.
   
    0.497
Hsp83
Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...]
      
 0.495
pie
Pineapple eye (pie) encodes a protein that contributes to viability of imaginal disc cells and affects germline stem cell renewal. It interacts genetically with the Jak/Stat and BMP pathways.
   
  
 0.462
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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