STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ImpE220-hydroxyecdysone protein; Probably has an essential role in embryogenesis, induces morphogenesis of imaginal disks, and may participate in multimolecular aggregates. (466 aa)    
Predicted Functional Partners:
Spn100A
Serpin 100A; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: negative regulation of endopeptidase activity; multicellular organism reproduction; Belongs to the serpin family.
   
    0.849
Spn43Aa
Serpin, putative; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: negative regulation of proteolysis; negative regulation of endopeptidase activity; Belongs to the serpin family.
   
    0.837
neo
Neyo, isoform A; It is involved in the biological process described with: apical constriction; regulation of embryonic cell shape.
   
 
 0.751
ImpE3
Ecdysone-inducible gene E3; It is involved in the biological process described with: imaginal disc eversion.
   
  
 0.670
Cpr12A
Cuticular protein 12A; Structural constituent of chitin-based larval cuticle; structural constituent of cuticle. It is involved in the biological process described with: chitin-based cuticle development.
   
  
 0.664
ImpE1
Ecdysone-inducible gene E1 (ImpE1) encodes a protein similar to a low-density lipoprotein (LDL) receptor. It is hypothesized to play a role in the cell rearrangements associated with morphogenesis of the disc epithelium. ImpE1 transcription is upregulated by 20-hydroxyecdysone.
   
  
 0.603
cysu
Curly Su; Peroxidase activity; heme binding. It is involved in the biological process described with: oxidation-reduction process; response to oxidative stress.
   
  
 0.544
ImpL1
Ecdysone-inducible gene L1, isoform B.
   
  
 0.529
wbl
Windbeutel (wbl) encodes a Toll signaling pathway member protein residing in the endoplasmic reticulum. It is required for the transport of the product of pip to the Golgi in ovarian follicle cells.
   
  
 0.514
mas
Protein masquerade; In embryogenesis, has a role in somatic muscle attachment and in the development of axonal pathways probably by stabilizing cell- matrix adhesion and/or by acting as a competitive antagonist of serine proteases.
   
    0.513
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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