STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FieFire exit, isoform A; Fire exit (Fie) is expressed in some peripheral glia cells and encodes a transmembrane protein that may be involved in intracellular transport during glial development. (250 aa)    
Predicted Functional Partners:
seq
Sequoia, isoform A; Sequoia (seq) encodes a pan-neuronally expressed zinc-finger transcription factor that governs dendrite and axon outgrowth. It is necessary for the proper development of tracheal branches and dendritic branches of multidendritic neurons, as well as development of the R8 cell in eye development.
      
 0.740
CG8034
Uncharacterized protein, isoform A; Monocarboxylic acid transmembrane transporter activity. It is involved in the biological process described with: monocarboxylic acid transport; transmembrane transport.
      
 0.670
CG5535
Uncharacterized protein, isoform C; L-ornithine transmembrane transporter activity; amino acid transmembrane transporter activity; L-lysine transmembrane transporter activity; arginine transmembrane transporter activity. It is involved in the biological process described with: amino acid transmembrane transport; L-ornithine transmembrane transport; amino acid transport; L-arginine import across plasma membrane.
      
 0.670
CG5646
SD08189p; Acyl carnitine transmembrane transporter activity; transmembrane transporter activity. It is involved in the biological process described with: amino acid transport; acyl carnitine transport; Belongs to the mitochondrial carrier (TC 2.A.29) family.
   
  
 0.669
Ice1
Little elongation complex subunit 1; Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies. Belongs to the ICE1 family.
      
 0.664
Alp11
Alkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation.
      
 0.664
qua
Villin-like protein quail; Required for the formation of cytoplasmic actin filament bundles in nurse cells, possibly by regulating both the polymerization and organization of actin filaments. Mutations in quail result in female sterility due to the disruption of cytoplasmic transport from the nurse cells into the oocyte late in oogenesis.
      
 0.652
Cyp309a1
Probable cytochrome P450 309a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
      
 0.495
Samuel
SAM-motif ubiquitously expressed punctatedly localized protein (Samuel) encodes a protein that binds to the nuclear receptor encoded by Hr78 and acts as a corepressor. It regulates chromatin silencing and larval growth.
      
 0.493
CG14907
Uncharacterized protein.
      
 0.491
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.