Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mgeMitochondrial import protein; Maggie (mge) encodes a protein predicted to act as a receptor of the TOM (translocase of outer membrane) complex, which is involved in protein import into mitochondria. The product of mge modulates cell death induced by the expression of the mouse Bax protein. (148 aa)    
Predicted Functional Partners:
Tom7
Translocase of outer membrane 7 (Tom7) encodes a putative mitochondrial protein that may act as a channel component of the TOM complex based on orthology with the human gene TOMM7.
   
 0.999
Tom40
Mitochondrial import receptor subunit TOM40 homolog 1; Translocase of outer membrane 40 (Tom40) encodes a protein predicted to be a channel component of the TOM complex, which is involved in protein import into mitochondria. It is predicted to be involved in the cellular response to hypoxia.
   
 0.998
Tom70
Translocase of outer membrane 70 (Tom70) encodes a mitochondrial protein that may act as a receptor of the TOM complex based on orthology. TOM complex is involved in protein import into mitochondria. The product of Tom70 modulates cell death induced by the expression of the mouse Bax protein.
   
 0.996
Tom20
Translocase of outer membrane 20, isoform A; Mitochondrion targeting sequence binding; P-P-bond-hydrolysis-driven protein transmembrane transporter activity. It is involved in the biological process described with: protein targeting to mitochondrion; tRNA import into mitochondrion; mitochondrial outer membrane translocase complex assembly; protein import into mitochondrial matrix.
   
 0.996
tomboy20
GEO10511p1; P-P-bond-hydrolysis-driven protein transmembrane transporter activity; mitochondrion targeting sequence binding. It is involved in the biological process described with: protein targeting to mitochondrion; protein import into mitochondrial matrix; mitochondrial outer membrane translocase complex assembly; tRNA import into mitochondrion.
   
 0.994
CG7639
SAM50-like protein CG7639; May play a role in the maintenance of the structure of mitochondrial cristae; Belongs to the SAM50/omp85 family.
   
 0.993
CG9393
Metaxin-1 homolog; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity); Belongs to the metaxin family.
   
 0.990
CG34200
GEO13367p1.
   
  0.989
tomboy40
Mitochondrial import receptor subunit TOM40 homolog 2; Channel-forming protein essential for import of protein precursors into mitochondria; Belongs to the Tom40 family.
   
 0.985
CG4520
IP11229p; Protein transmembrane transporter activity. It is involved in the biological process described with: protein import into mitochondrial matrix.
   
 0.985
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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