STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ras64BRas-like protein 2; May be involved in endocytic processes and/or other transport pathways mediated by vesicle trafficking. May interact functionally with ROP protein. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (192 aa)    
Predicted Functional Partners:
Ras85D
Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.
  
 
0.925
ras
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
    
 
 0.847
Raf
Raf homolog serine/threonine-protein kinase Raf; Serine/threonine kinase required in the early embryo for the formation of terminal structure. Also required during the proliferation of imaginal cells. May act downstream of Ras85D in the tor signal transduction pathway. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
   
 
 0.815
Lrrk
Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response.
  
 
 0.750
Nf1
Neurofibromin 1 (Nf1) encodes a protein that functions as a GTPase activating protein for the products of Ras85D and Ras64B in the larval and adult nervous system. Loss of Nf1 results in excess Ras-Raf-ERK signaling and to a non-cell-autonomous cAMP/PKA signaling defect. The product of Nf1 contributes to postembryonic growth, learning/memory, and circadian rhythm.
    
 
 0.732
Pka-C1
cAMP-dependent protein kinase catalytic subunit 1; Serine/threonine-protein kinase involved in memory formation. Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane.
   
 
 0.710
Pka-C2
ATP binding; protein serine/threonine kinase activity; cAMP-dependent protein kinase activity; protein kinase A regulatory subunit binding. It is involved in the biological process described with: protein kinase A signaling; peptidyl-serine phosphorylation.
   
 
 0.703
ACXC
Adenylyl cyclase X C, isoform A; Adenylate cyclase activity. It is involved in the biological process described with: cyclic nucleotide biosynthetic process; spermatogenesis; adenylate cyclase-activating G protein-coupled receptor signaling pathway.
    
 
 0.659
ACXB
Adenylyl cyclase X B; Adenylate cyclase activity. It is involved in the biological process described with: spermatogenesis; cyclic nucleotide biosynthetic process; adenylate cyclase-activating G protein-coupled receptor signaling pathway.
    
 
 0.659
CG32301
Uncharacterized protein, isoform C; Adenylate cyclase activity. It is involved in the biological process described with: adenylate cyclase-activating G protein-coupled receptor signaling pathway; chaeta development; notum development; cyclic nucleotide biosynthetic process.
    
 
 0.659
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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