| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CG18132 | CaBP1 | FBpp0077585 | FBpp0311643 | IP08350p; It is involved in the biological process described with: cell redox homeostasis; apoptotic cell clearance. | Protein disulfide-isomerase A6 homolog; Calcium-binding protein 1 (CaBP1) encodes a protein that resides in the lumen of the endoplasmic reticulum. It seems to be relocated outside cells during apoptosis and involved in the phagocytosis of apoptotic cells. | 0.935 |
| CG18132 | Ero1L | FBpp0077585 | FBpp0073073 | IP08350p; It is involved in the biological process described with: cell redox homeostasis; apoptotic cell clearance. | Ero1-like protein; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes pdi-1, the enzyme catalyzing protein disulfide formation, in order to allow pdi-1 to sustain additional rounds of disulfide formation. Following pdi reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity); Belongs to the EROs family. | 0.941 |
| CG18132 | Hsc70-3 | FBpp0077585 | FBpp0073447 | IP08350p; It is involved in the biological process described with: cell redox homeostasis; apoptotic cell clearance. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins (By similarity). Acts as a key repressor of the unfolded protein response (UPR) (By similarity). | 0.843 |
| CG18132 | Pdi | FBpp0077585 | FBpp0312224 | IP08350p; It is involved in the biological process described with: cell redox homeostasis; apoptotic cell clearance. | Protein disulfide-isomerase; Participates in the folding of proteins containing disulfide bonds. | 0.946 |
| CG18132 | prtp | FBpp0077585 | FBpp0073396 | IP08350p; It is involved in the biological process described with: cell redox homeostasis; apoptotic cell clearance. | Thioredoxin domain-containing protein 5 homolog; Possesses thioredoxin activity (By similarity). Acts as a ligand for Drpr and is required for the phagocytosis of apoptotic cells. Binds to the extracellular region of Drpr and augments Drpr tyrosine phosphorylation ; Belongs to the protein disulfide isomerase family. | 0.900 |
| CG18132 | wbl | FBpp0077585 | FBpp0309412 | IP08350p; It is involved in the biological process described with: cell redox homeostasis; apoptotic cell clearance. | Windbeutel (wbl) encodes a Toll signaling pathway member protein residing in the endoplasmic reticulum. It is required for the transport of the product of pip to the Golgi in ovarian follicle cells. | 0.916 |
| CG33303 | CaBP1 | FBpp0304506 | FBpp0311643 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] | Protein disulfide-isomerase A6 homolog; Calcium-binding protein 1 (CaBP1) encodes a protein that resides in the lumen of the endoplasmic reticulum. It seems to be relocated outside cells during apoptosis and involved in the phagocytosis of apoptotic cells. | 0.747 |
| CG33303 | Ero1L | FBpp0304506 | FBpp0073073 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] | Ero1-like protein; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes pdi-1, the enzyme catalyzing protein disulfide formation, in order to allow pdi-1 to sustain additional rounds of disulfide formation. Following pdi reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity); Belongs to the EROs family. | 0.898 |
| CG33303 | Hsc70-3 | FBpp0304506 | FBpp0073447 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins (By similarity). Acts as a key repressor of the unfolded protein response (UPR) (By similarity). | 0.894 |
| CG33303 | Pdi | FBpp0304506 | FBpp0312224 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] | Protein disulfide-isomerase; Participates in the folding of proteins containing disulfide bonds. | 0.423 |
| CG33303 | Sec13 | FBpp0304506 | FBpp0311988 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II. Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development. Required for reactivation of transcription after heat shock. Required for nuclear import of phosphorylated Mad via importin msk. Has no role i [...] | 0.924 |
| CG7011 | Ero1L | FBpp0075398 | FBpp0073073 | GH25868p; It is involved in the biological process described with: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; endoplasmic reticulum to Golgi vesicle-mediated transport. | Ero1-like protein; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes pdi-1, the enzyme catalyzing protein disulfide formation, in order to allow pdi-1 to sustain additional rounds of disulfide formation. Following pdi reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity); Belongs to the EROs family. | 0.887 |
| CG7011 | Hsc70-3 | FBpp0075398 | FBpp0073447 | GH25868p; It is involved in the biological process described with: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; endoplasmic reticulum to Golgi vesicle-mediated transport. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins (By similarity). Acts as a key repressor of the unfolded protein response (UPR) (By similarity). | 0.476 |
| CG7011 | Sec13 | FBpp0075398 | FBpp0311988 | GH25868p; It is involved in the biological process described with: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; endoplasmic reticulum to Golgi vesicle-mediated transport. | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II. Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development. Required for reactivation of transcription after heat shock. Required for nuclear import of phosphorylated Mad via importin msk. Has no role i [...] | 0.543 |
| CaBP1 | CG18132 | FBpp0311643 | FBpp0077585 | Protein disulfide-isomerase A6 homolog; Calcium-binding protein 1 (CaBP1) encodes a protein that resides in the lumen of the endoplasmic reticulum. It seems to be relocated outside cells during apoptosis and involved in the phagocytosis of apoptotic cells. | IP08350p; It is involved in the biological process described with: cell redox homeostasis; apoptotic cell clearance. | 0.935 |
| CaBP1 | CG33303 | FBpp0311643 | FBpp0304506 | Protein disulfide-isomerase A6 homolog; Calcium-binding protein 1 (CaBP1) encodes a protein that resides in the lumen of the endoplasmic reticulum. It seems to be relocated outside cells during apoptosis and involved in the phagocytosis of apoptotic cells. | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] | 0.747 |
| CaBP1 | Ero1L | FBpp0311643 | FBpp0073073 | Protein disulfide-isomerase A6 homolog; Calcium-binding protein 1 (CaBP1) encodes a protein that resides in the lumen of the endoplasmic reticulum. It seems to be relocated outside cells during apoptosis and involved in the phagocytosis of apoptotic cells. | Ero1-like protein; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes pdi-1, the enzyme catalyzing protein disulfide formation, in order to allow pdi-1 to sustain additional rounds of disulfide formation. Following pdi reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity); Belongs to the EROs family. | 0.964 |
| CaBP1 | Hsc70-3 | FBpp0311643 | FBpp0073447 | Protein disulfide-isomerase A6 homolog; Calcium-binding protein 1 (CaBP1) encodes a protein that resides in the lumen of the endoplasmic reticulum. It seems to be relocated outside cells during apoptosis and involved in the phagocytosis of apoptotic cells. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins (By similarity). Acts as a key repressor of the unfolded protein response (UPR) (By similarity). | 0.997 |
| CaBP1 | Pdi | FBpp0311643 | FBpp0312224 | Protein disulfide-isomerase A6 homolog; Calcium-binding protein 1 (CaBP1) encodes a protein that resides in the lumen of the endoplasmic reticulum. It seems to be relocated outside cells during apoptosis and involved in the phagocytosis of apoptotic cells. | Protein disulfide-isomerase; Participates in the folding of proteins containing disulfide bonds. | 0.976 |
| CaBP1 | Xbp1 | FBpp0311643 | FBpp0301746 | Protein disulfide-isomerase A6 homolog; Calcium-binding protein 1 (CaBP1) encodes a protein that resides in the lumen of the endoplasmic reticulum. It seems to be relocated outside cells during apoptosis and involved in the phagocytosis of apoptotic cells. | X box binding protein-1 (Xbp1) encodes a transcription factor that mediates the unfolded protein response. Xbp1 mRNA undergoes splicing after being cleaved by the product of Ire1, inducing the expression of ER quality control transcripts. Xbp1 mutants fail to develop beyond the 2nd instar larval stage, indicative of a requirement to resolve inherent ER stress during normal development. | 0.636 |
