STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tipEProtein tipE; Enhances para sodium channel function. Required during pupal development to rescue adult paralysis and also protects adult flies against heat-induced lethality. (452 aa)    
Predicted Functional Partners:
Teh4
TipE-like protein 4; Sodium channel regulator activity. It is involved in the biological process described with: regulation of sodium ion transport.
 
 
  
 0.926
Teh3
TipE-like protein 3; tipE homolog 3 (Teh3) encodes a protein involved in regulation of sodium transport.
 
 
  
 0.893
para
Sodium channel protein para; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Belongs to the sodium channel (TC 1.A.1.10) family. Para subfamily.
   
 
 0.872
CG15270
Anoctamin; Intracellular calcium activated chloride channel activity; calcium activated cation channel activity. It is involved in the biological process described with: chloride transport; cation transport; transmembrane transport.
   
    0.718
CG18675
Cilia- and flagella-associated protein 298; It is involved in the biological process described with: regulation of cilium movement; Belongs to the CFAP298 family.
 
 
  
 0.684
NaCP60E
Na channel protein 60E (NaCP60E) encodes a voltage-gated calcium-selective cation channel that likely modulates the stability of neural circuits, particularly under environmental stresses; Belongs to the sodium channel (TC 1.A.1.10) family. NaCP60E subfamily.
   
  
 0.669
Liprin-gamma
Liprin-gamma, isoform C; Liprin-gamma (Liprin-gamma) encodes an adaptor protein that counteracts the functions of the product of Liprin-alpha in photoreceptor axon targeting and the product of Liprin-beta in neuromuscular junction development, potentially through competition for binding partners.
   
    0.638
CG42324
Uncharacterized protein, isoform K.
      
 0.610
VhaM9.7-c
V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
      
 0.495
sei
Putative potassium channel subunit homolog; Seizure (sei) encodes a protein involved in sound perception.
      
 0.495
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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