STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ctl1CTL-like protein 1; Transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport. (691 aa)    
Predicted Functional Partners:
Sod3
Superoxide dismutase 3 (Sod3) encodes an extra-cellular Cu Zn superoxide dismutase that can be produced as secreted and membrane bound forms. It converts oxygen free radicals to hydrogen peroxide and is involved in free radical defense and redox balance; Belongs to the Cu-Zn superoxide dismutase family.
   
  
 0.685
clt
Related juvenile hormone esterase; Carboxylic ester hydrolase activity. It is involved in the biological process described with: male mating behavior.
      
 0.664
Ppt1
Palmitoyl-protein thioesterase 1 (Ppt1) encodes a lysosomal enzyme that removes palmitoyl groups from particular target proteins during protein degradation within the lysosomal compartment. Palmitoylation is critical for the cellular localization and modulation of many signaling proteins.
   
  
 0.631
sxc
Super sex combs (sxc) is a polycomb group gene that encodes a O-GlcNAc transferase involved in epigenetic gene silencing.
   
    0.624
CG3223
GH08043p; Polyubiquitin modification-dependent protein binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process.
   
  
 0.530
Fign
Fidgetin-like protein 1; ATP binding; magnesium ion binding; ATPase activity; microtubule-severing ATPase activity; hydrolase activity.
      
 0.461
Bro
Brother (Bro) encodes a beta-subunit of the transcription factor complex core binding factor, which is involved in transcription regulation. It regulates hemocyte proliferation and acts redundantly with the product of Bgb in embryonic segmentation.
      
 0.430
LysP
Lysozyme P; Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food. Belongs to the glycosyl hydrolase 22 family.
   
  
 0.427
spin
Protein spinster; Probable sphingolipid transporter that plays a central role in endosomes and/or lysosomes storage. Involved in TGF-beta-mediated synaptic growth regulation both pre- and postsynaptically via its function in endosomal storage regulation. Also required during oogenesis by regulating yolk spheres storage. Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
      
 0.424
Pif2
Protein binding.
      
 0.422
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.