STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
Ork1Open rectifier K[+] channel 1 (Ork1) encodes a member of the two pore open rectifier potassium channel gene family. It contributes to the regulation of membrane resting potential. The primary gating mechanism for the product of Ork1 appears to be based on phosphorylation of multiple serine, threonine and tyrosine residues in the large intracellular C-terminal tail. (1019 aa)    
Predicted Functional Partners:
CG43155
Uncharacterized protein; Potassium channel activity; potassium ion leak channel activity. It is involved in the biological process described with: stabilization of membrane potential; potassium ion transmembrane transport; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
  
  
0.742
Task6
TWIK-related acid-sensitive K[+] channel 6 (Task6) encodes an ion channel involved in the transmembrane transport of potassium.
     
0.672
Ih
I[[h]] channel (Ih) encodes a low-threshold, voltage-gated ion channel. It may influence excitatory postsynaptic potential kinetics and integration.
    
 
 0.662
CG1688
BcDNA.GH04802; Potassium channel activity; potassium ion leak channel activity. It is involved in the biological process described with: stabilization of membrane potential; potassium ion transmembrane transport; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
     
0.633
VhaM9.7-a
V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
      
 0.630
Task7
TWIK-related acid-sensitive K[+] channel 7 (Task7) encodes an ion channel involved in the transmembrane transport of potassium.
     
0.627
CG8712
AT09333p.
      
 0.609
sand
RE21922p; Potassium ion leak channel activity; potassium channel activity. It is involved in the biological process described with: negative regulation of membrane potential; negative regulation of circadian sleep/wake cycle, sleep; stabilization of membrane potential; potassium ion transmembrane transport; cellular response to dopamine; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
     
0.579
CG10864
Uncharacterized protein; Potassium ion leak channel activity; potassium channel activity. It is involved in the biological process described with: potassium ion transmembrane transport; stabilization of membrane potential; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
     
0.573
galene
FI03418p; Potassium channel activity; potassium ion leak channel activity. It is involved in the biological process described with: potassium ion transmembrane transport; stabilization of membrane potential; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
     
0.569
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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