STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
sofeSister of feo, isoform A; Microtubule binding. It is involved in the biological process described with: mitotic cytokinesis; G protein-coupled receptor signaling pathway; mitotic spindle midzone assembly; microtubule cytoskeleton organization. (607 aa)    
Predicted Functional Partners:
pav
Kinesin-like protein; Pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity.
   
 
 0.959
Klp3A
Kinesin-like protein at 3A (Klp3A) encodes a microtubule motor protein involved in chromosome segregation and mitotic spindle morphogenesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
 
 0.922
polo
Serine/threonine-protein kinase polo; May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle. Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles. Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
   
 
 0.888
asp
Protein abnormal spindle; Required to maintain the structure of the centrosomal microtubule organizing center (MTOC) during mitosis. May have a preferential role in regulating neurogenesis. Required for germ cell mitosis and oocyte differentiation.
   
  
 0.869
cmet
CENP-meta, isoform C; CENP-meta (cmet) encodes a kinetochore kinesin that contributes to metaphase chromosome alignment; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
 
 0.835
Mps1
Monopolar spindle 1, isoform B; Monopolar spindle 1 (Mps1) encodes a conserved protein kinase that is associated with kinetochores and is required for the mitotic and meiotic spindle assembly checkpoints.
   
  
 0.830
Klp61F
Kinesin-like protein Klp61F; Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function. Forms cross-links between microtubules within interpolar microtubule bundles. Contributes to the length of the metaphase spindle, maintains the prometaphase spindle by antagonizing Ncd, drives anaphase B, and also contributes to normal chromosome congression, kinet [...]
   
 
 0.827
CG32318
RT07324p; ATP-dependent microtubule motor activity, plus-end-directed; microtubule motor activity; ATP binding; microtubule binding. It is involved in the biological process described with: microtubule-based movement; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
 
 0.822
cana
CENP-ana, isoform A; CENP-ana (cana) encodes a kinetochore kinesin that contributes to metaphase chromosome alignment; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
 
 0.820
tum
Tumbleweed (tum) encodes a GTPase activating protein for Rho family GTPases involved in Wnt signalling regulation.
   
 
 0.805
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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