STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Gapvd1Receptor-mediated endocytosis protein 6 homolog; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis. Belongs to the GAPVD1 family. (1712 aa)    
Predicted Functional Partners:
Rab5
Rab5, isoform A; Rab5 (Rab5) encodes a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering the activity of the product of Rab5 affects many receptor-mediated signaling pathways as well as epithelial polarity.
    
 
 0.929
Rbpn-5
Rabaptin-5 (Rbpn-5) encodes a Rab GTPase binding protein involved in regulation of endosome size.
   
 
 0.897
Rab21
Rab21, isoform C; GTP binding; GTPase activity; phosphatidylinositol 3-kinase catalytic subunit binding; protein binding. It is involved in the biological process described with: Rab protein signal transduction; intracellular protein transport; vesicle-mediated transport; positive regulation of autophagosome maturation; cortical actin cytoskeleton organization.
   
 
 0.831
Vps29
Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
    
 
 0.823
eIF2Bbeta
Eukaryotic translation initiation factor 2B subunit beta; Translation initiation factor activity; guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: cellular response to hypoxia; regulation of translational initiation; translational initiation; Belongs to the eIF-2B alpha/beta/delta subunits family.
    
   0.735
CG41099
Uncharacterized protein, isoform C; Metal ion binding. It is involved in the biological process described with: epithelial cell morphogenesis; embryonic morphogenesis; endocytosis.
   
 
 0.732
RabX1
Rab-related GTP-binding protein Chrowded; Rab10 (Rab10) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in basement membrane organization.
   
 
 0.718
Als2
Alsin homolog; Has guanine nucleotide exchange factor (GEF) activity towards Rab5. Promotes the exchange of GDP to GTP, converting inactive GDP- bound Rab5 into its active GTP-bound form.
  
 
 0.684
CG2157
Uncharacterized protein, isoform B.
   
 
 0.673
CG11122
Uncharacterized protein; Nucleic acid binding.
   
 
 0.670
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.