STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Gs2Glutamine synthetase 2 (Gs2) encodes an enzyme that converts glutamate to glutamine. It is expressed in the embryonic nervous system and regulates the size of glutamate neurotransmitter pools and synapse assembly. (373 aa)    
Predicted Functional Partners:
Gdh
Glutamate dehydrogenase, mitochondrial; Glutamate dehydrogenase (Gdh) encodes a glutamate dehydrogenase involved glutamate metabolism.
  
 
 0.969
CG9674
Uncharacterized protein, isoform F; It is involved in the biological process described with: glutamate biosynthetic process; ammonia assimilation cycle; oxidation-reduction process.
  
 
 0.966
r
Glutamine-dependent carbamoyl-phosphate synthase; Rudimentary (r) encodes the CAD protein that catalyzes the initial steps of de novo pyrimidine biosynthesis. r depletion results in wing malformations and pyrimidine auxotrophy.
  
 
 0.954
Prat
Amidophosphoribosyltransferase; Phosphoribosylamidotransferase (Prat) encodes a type-2 glutamine amidotransferase that converts phosphoribosylpyrophosphate to phosphoribosylamine using glutamine. It is an essential enzyme in the pathway for de novo synthesis of the purine nucleotide inosine monophosphate (IMP). IMP is the precursor for purine nucleotides required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
    
 0.950
P5CS
Delta-1-pyrroline-5-carboxylate synthase; Glutamate-5-semialdehyde dehydrogenase activity; glutamate 5-kinase activity; delta1-pyrroline-5-carboxylate synthetase activity. It is involved in the biological process described with: oxidation-reduction process; proline biosynthetic process; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
  
 
 0.948
Gfat2
Glutamine:fructose-6-phosphate aminotransferase 2; Glutamine-fructose-6-phosphate transaminase (isomerizing) activity; carbohydrate derivative binding. It is involved in the biological process described with: UDP-N-acetylglucosamine metabolic process; fructose 6-phosphate metabolic process; protein N-linked glycosylation.
  
 
 0.945
Gfat1
Glutamine:fructose-6-phosphate aminotransferase 1, isoform A; Glutamine-fructose-6-phosphate transaminase (isomerizing) activity; carbohydrate derivative binding. It is involved in the biological process described with: carbohydrate derivative biosynthetic process.
  
 
 0.945
Prat2
Amidophosphoribosyltransferase; Phosphoribosylamidotransferase 2 (Prat2) encodes a type-2 glutamine amidotransferase that is essential in the pathway for de novo synthesis of inosine monophosphate (IMP). IMP is the precursor for purine nucleotides that are required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.944
P5CDh1
delta-1-Pyrroline-5-carboxylate dehydrogenase 1 (P5CDh1) encodes a conserved, nuclear-encoded mitochondrial matrix enzyme. It is a member of the aldehyde dehydrogenase superfamily involved in proline degradation.
  
 
 0.944
GLS
Glutaminase, isoform H; Glutaminase activity. It is involved in the biological process described with: glutamine catabolic process; glutamine metabolic process; glutamate biosynthetic process.
    
 0.938
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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