Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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co-expression
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gene co-occurrence
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rho-4Rhomboid-4, isoform A; Rhomboid-4 (rho-4) encodes a member of the rhomboid superfamily of intramembrane serine proteases, which cleave to release proteins from the membrane. It processes the transmembrane EGF ligands encoded by spi, Krn, and grk. Its activity is directly and dramatically stimulated by calcium; Belongs to the peptidase S54 family. (417 aa)    
Predicted Functional Partners:
spi
Protein spitz; Ligand for the EGF receptor (Gurken). Involved in a number of unrelated developmental choices, for example, dorsal-ventral axis formation, glial migration, sensory organ determination, and muscle development. It is required for photoreceptor determination.
   
 
 0.939
Krn
LD34429p; Keren (Krn) encodes an ligand for the receptor encoded by Egfr that is processed by the products of S and rho. It shows a redundant role with the products of spi in very few tissues.
    
   0.786
grk
Protein gurken; Critical for defining the anterior-posterior and dorsal- ventral axes of the egg. May signal directly to dorsal follicle cells through the receptor torpedo (top). During oogenesis this signaling pathway instructs follicle cells to follow a dorsal pathway of development rather than the default ventral pathway.
   
 
 0.783
Psn
Presenilin homolog; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. Belongs to the peptidase A22A family.
      
 0.563
CG32320
DC_STAMP domain-containing protein.
      
 0.472
RhoGAP92B
Rho GTPase-activating protein 92B; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
   
  
 0.465
Phb2
Prohibitin.
   
 
 0.407
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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