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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SelGSelenoprotein G (SelG) encodes a type III Golgi apparatus transmembrane protein. It is implicated in the release of Ca[2+] from the endoplasmic reticulum to the cytosol by regulating the expression of genes participating in the inositol 1,4,5-tris-phosphate pathway. (110 aa)    
Predicted Functional Partners:
BthD
Selenoprotein BthD; May be involved in a redox-related process. Required for survival and specifically for salivary gland morphogenesis.
      
 0.873
Sps2
Selenide, water dikinase 2; Selenophosphate synthetase 2 (Sps2) is essential for selenoprotein biosynthesis. It encodes an enzyme that catalyzes the synthesis of selenophosphate from selenide and/or other selenium metabolites. Selenophosphate is an active selenium donor for the formation of selenocysteine.
   
  
 0.740
CG1578
LD05643p; Diphthine-ammonia ligase activity. It is involved in the biological process described with: peptidyl-diphthamide biosynthetic process from peptidyl-histidine.
      
 0.670
kel
Ring canal kelch protein; Kelch (kel) encodes a substrate targeting component of a Cullin3-RING ubiquitin E3 ligase. It binds F-actin in vitro, while its predominant in vivo function is in the ubiquitin-proteasome pathway. It has an essential role in oogenesis, where it is required for cytoskeletal organization in ovarian ring canals.
      
 0.626
SecS
O-phosphoseryl-tRNA(Sec) selenium transferase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis.
   
  
 0.616
Pstk
SD05444p2; tRNA binding.
      
 0.596
Rbbp5
Retinoblastoma-binding protein 5 homolog; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which also methylates histone H3 'Lys-4'.
    
 
 0.576
Secp43
RE72132p; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; mRNA splice site selection.
   
 
 0.560
CG7484
CG7484 protein; Oxidoreductase activity; disulfide oxidoreductase activity. It is involved in the biological process described with: cell redox homeostasis.
   
  
 0.553
ash2
Set1/Ash2 histone methyltransferase complex subunit ASH2; Transcriptional regulator. Regulates a number of genes involved in wing development including activation of net and bs and repression of rho and kni and controls vein-intervein patterning during wing development. Required for correct expression of a number of homeotic genes including Scr in the first leg imaginal disk and Ubx in the third leg imaginal disk and haltere disks. Required for stabilization of the histone-lysine N-methyltransferase trr and for trimethylation of 'Lys-4' of histone H3. Plays a role in maintenance of tra [...]
    
 
 0.540
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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