Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CG1806LP03706p. (399 aa)    
Predicted Functional Partners:
Dg
Dystroglycan, isoform D; Dystroglycan (Dg) encodes a major non-integrin extracellular matrix (ECM) receptor that connects the ECM to the actin cytoskeleton. It regulates animal survival and temperature preference, muscle integrity, myotendinous and neuromuscular junction formation and function, nervous system development, axon pathfinding, rhabdomere differentiation, neuronal stem cell division and epithelial polarity.
    
 0.987
Hexo1
Beta-hexosaminidase; Hexosaminidase 1 (Hexo1) encodes a beta-N-acetylglucosaminidase involved in protein deglycosylation and rhodopsin biosynthesis.
    
   0.977
CG5568
LD47944p; CoA-ligase activity; fatty acid ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process.
    
   0.972
Scgdelta
Gamma/delta-sarcoglycan-like protein SCG-GAMMA/DELTA; Sarcoglycan delta (Scgdelta) encodes a transmembrane protein that is required for normal muscle structure and function. It contributes to sarcomere organization and heart contraction.
   
 0.963
Scgalpha
Sarcoglycan alpha, isoform C; Structural constituent of muscle; calcium ion binding.
   
 0.949
CG7737
Uncharacterized protein, isoform B; Polyamine oxidase activity; oxidoreductase activity. It is involved in the biological process described with: oxidation-reduction process.
    
   0.836
Dyb
Dystrobrevin, isoform F; Zinc ion binding; structural constituent of muscle. It is involved in the biological process described with: synaptic signaling.
    
 0.806
Scgbeta
Sarcoglycan beta (Scgbeta) encodes a component of the sarcoglycan complex, which is a sub-complex of the dystrophin glycoprotein complex. The product of Scgbeta negatively regulates the EGFR signaling pathway in eye imaginal discs.
    
  0.791
Dys
Dystrophin, isoforms A/C/F/G/H; Required for the maintenance of appropriate synaptic retrograde communication and the stabilization of muscle cell architecture or physiology. Both det and Dg are required for maintenance of early dpp signaling in the presumptive crossvein. Isoform A is not required to maintain muscle integrity, but plays a role in neuromuscular homeostasis by regulating neurotransmitter release. May play a role in anchoring the cytoskeleton to the plasma membrane.
    
 0.776
dah
Discontinuous actin hexagon (dah) encodes a protein required for cortical furrows during early embryogenesis that is recruited to the membrane in a process dependent on the product of nuf.
    
 0.708
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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