STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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[Homology]
Score
Lsm12aLSM12 homolog A; Component of the Atx2-tyf activator complex which functions in the circadian pacemaker neurons to activate the TYF-dependent translation of per and maintain 24 hour periodicity in circadian behaviors. Within the Atx2-tyf complex, likely to function as a molecular adapter which stabilizes the interaction between Atx2 and the translational regulator tyf. (217 aa)    
Predicted Functional Partners:
Atx2
Ataxin-2 homolog; RNA binding protein that regulates various processes including circadian behaviors, actin filament formation, eye development and oocyte formation. Forms a complex with tyf and pAbp which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B. Forms an activator complex (Atx2-tyf activator complex) via association with Lsm12a and activates the TYF-dependent translation of per to maintain 24 hour periodicity in circadian [...]
    
 0.993
tyf
Twenty-four, isoform B; Twenty-four (tyf) encodes a protein that forms a complex together with the products of Atx2 and Lsm12. This complex binds per mRNA and activates its translation to sustain circadian rhythms. The tyf product is also involved in immune defense against Listeria monocytogenes infection.
   
 0.973
Hez
Protein Hezron.
  
  
0.919
me31B
ATP-dependent RNA helicase me31b; ATP-dependent RNA helicase which is a core component of a variety of ribonucleoprotein complexes (RNPs) that play critical roles in translational repression and mRNA decapping during embryogenesis, oogenesis, neurogenesis and neurotransmission. Recruits core components and translational repressors to some RNP complexes, and mediates RNP aggregation into processing granules such as P-bodies. As part of a RNP complex containing tral, eIF4E1, cup, and pAbp, involved in RNP-mediated translational repression of maternal mRNAs during oogenesis and embryogene [...]
   
 
 0.914
Secp43
RE72132p; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; mRNA splice site selection.
   
   0.739
CG6610
U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA; Belongs to the snRNP Sm proteins family.
   
  
 0.723
LSm3
U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.
   
 
 0.711
LSm7
Like Sm 7, isoform A; RNA binding. It is involved in the biological process described with: nuclear-transcribed mRNA catabolic process; mRNA splicing, via spliceosome.
   
  
 0.703
CG33108
UPF0692 protein CG33108; Belongs to the UPF0692 family.
    
 
 0.698
pAbp
Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Since it interacts with the cap-associating translation initiation factor eIF4G, it is likely that it functions by linking Atx2 to the cap-binding complex. Forms a complex with tyf and Atx2 which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B, respectively. The activator complex (Atx2-tyf activator complex) activates the TYF-dependent translation of per to maintain 24 [...]
   
 
 0.694
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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